(2-hydroxypropyl)trimethylammonium 2-ethylhexanoate

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

2017

Justification for type of information:

Read-Across from (2-hydroxypropyl)trimethylammonium formate is claimed as valid for assessment of the quaternary ammonium cation, and on the basis that 2-ethylhexamoic acid does not undergo hydrolysis due to lack of hydrolysable groups.
Justification attached.

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Preliminary study:

The preliminary study found the substance to be hydrolytically stable.

Transformation products:

not measured

Key result

pH:

7

Temp.:

25 °C

DT50:

> 1 yr

pH:

4

Temp.:

25 °C

DT50:

> 1 yr

pH:

9

Temp.:

25 °C

DT50:

> 1 yr

Validity criteria fulfilled:

yes

Conclusions:

The estimated half-life at 25 °C, monitoring the hydroxypropyl, 2-, trimethylammonium content of the test item was >1 year at pH 4, 7 and 9

Description of key information

Based on a study using (2 -hydroxypropyl)trimethylammonium formate, the estimated half-life at 25 °C, monitoring the hydroxypropyl, 2 ,trimethylammonium content of the test item was >1 year at pH 4, 7 and 9. This value is selected for chemical safety assessment.

2 -Ethylhexanoic aacid is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups.

Key value for chemical safety assessment

Half-life for hydrolysis:

1 yr

at the temperature of:

25 °C