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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
2017
Justification for type of information:
Read-Across from (2-hydroxypropyl)trimethylammonium formate is claimed as valid for assessment of the quaternary ammonium cation, and on the basis that 2-ethylhexamoic acid does not undergo hydrolysis due to lack of hydrolysable groups.
Justification attached.
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Preliminary study:
The preliminary study found the substance to be hydrolytically stable.
Transformation products:
not measured
Key result
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
pH:
9
Temp.:
25 °C
DT50:
> 1 yr
Validity criteria fulfilled:
yes
Conclusions:
The estimated half-life at 25 °C, monitoring the hydroxypropyl, 2-, trimethylammonium content of the test item was >1 year at pH 4, 7 and 9

Description of key information

Based on a study using (2 -hydroxypropyl)trimethylammonium formate, the estimated half-life at 25 °C, monitoring the hydroxypropyl, 2 ,trimethylammonium content of the test item was >1 year at pH 4, 7 and 9. This value is selected for chemical safety assessment.

2 -Ethylhexanoic aacid is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups.

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
25 °C

Additional information