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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
2,2',2''-nitrilotriethanol
EC Number:
203-049-8
EC Name:
2,2',2''-nitrilotriethanol
Cas Number:
102-71-6
Molecular formula:
C6H15NO3
IUPAC Name:
2,2',2''-nitrilotriethanol
Test material form:
liquid: viscous
Specific details on test material used for the study:
- Name of test material (as cited in study report): Triethanolamine derived from NH3 and Triethanolamine derived from DEA
- Lot-No.: test substance from NH3: jefferson 50303 and test substance from DEA: 2H1763
- Analytical purity: test substance derived from NH3: 91.8 %;
- Analytical purity: test substance derived from DEA: 88.1 %;
- Impurities: both test substances contain DEA as a major impurity of about 6.5 %, the DEA derived test substance additionally includes TEA-1EO at 4.4 %

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Intact and abraded skin was tested.
Doses:
- DEA-derived test substance: 2000 mg/kg bw
- NH3-derived test substance: 2000 mg/kg bw
No. of animals per sex per dose:
- DEA-derived test substance: 3 animals tested with intact skin and 3 animals tested with abraded skin (6 in total)
- NH3-derived test substance: 3 animals tested with intact skin and 3 animals tested with abraded skin (6 in total)
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality occurred in all test groups.
Clinical signs:
- DEA-derived test substance: moderate erythema at 24 hours (intact and abraded skin) returning to normal on day 10
- NH3-derived test substance: mild erythema at 24 hours (intact and abraded skin) returning to normal on day 6
Body weight:
All animals showed body weight gain during the course of the study

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met