1,2,4-Benzenetricarboxylic acid, mixed branched tridecyl and isodecyl esters

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Study period:

1981

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Conducted to sound scientific principles. GLP.

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1981

Reference 2

Reference Type:

publication

Title:

Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate

Author:

OECD SIDS

Year:

2002

Bibliographic source:

SIDS Initial Assessment Report for Siam 14-Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Version / remarks:

Procedure set forth in the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA)

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate

IUPAC Name:

Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate

Constituent 2

Reference substance name:

Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

EC Number:

222-020-0

EC Name:

Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

Cas Number:

3319-31-1

Molecular formula:

C33H54O6

IUPAC Name:

tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

Constituent 3

Reference substance name:

Nuoplaz 6959

IUPAC Name:

Nuoplaz 6959

Details on test material:

Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate
Source: Nouplaz 6959 Purity: 98.95%

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

Covered contact for 24 hours with abraded skin exposed 10% of the body surface area. Observation for 14 days follwed by gross necropsy.

Duration of exposure:

24 h

Doses:

1970 mg/kg/bw

No. of animals per sex per dose:

No. of animals per sex per dose: 3 per sex

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 1 970 mg/kg bw

Based on:

test mat.

Remarks on result:

other: no mortality was observed

Mortality:

no mortality was observed

Clinical signs:

other: No toxic signs

Gross pathology:

Nothing noted.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LD50 was > 1970 mg/kg for male and female rabbits.

Classification as a dermal toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/548/EEC for dangerous substances and Directive 1999/45/EC for preparations.

Executive summary:

The LD50 was > 1970 mg/kg for male and female rabbits.

Classification as a dermal toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/548/EEC for dangerous substances and Directive 1999/45/EC for preparations.