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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
1981
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Conducted to sound scientific principles. GLP.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1981
Reference Type:
publication
Title:
Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate
Author:
OECD SIDS
Year:
2002
Bibliographic source:
SIDS Initial Assessment Report for Siam 14-Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Version / remarks:
Procedure set forth in the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate
IUPAC Name:
Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate
Constituent 2
Chemical structure
Reference substance name:
Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
EC Number:
222-020-0
EC Name:
Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
Cas Number:
3319-31-1
Molecular formula:
C33H54O6
IUPAC Name:
tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
Constituent 3
Reference substance name:
Nuoplaz 6959
IUPAC Name:
Nuoplaz 6959
Details on test material:
Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate
Source: Nouplaz 6959 Purity: 98.95%

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Covered contact for 24 hours with abraded skin exposed 10% of the body surface area. Observation for 14 days follwed by gross necropsy.
Duration of exposure:
24 h
Doses:
1970 mg/kg/bw
No. of animals per sex per dose:
No. of animals per sex per dose: 3 per sex
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 1 970 mg/kg bw
Based on:
test mat.
Remarks on result:
other: no mortality was observed
Mortality:
no mortality was observed
Clinical signs:
other: No toxic signs
Gross pathology:
Nothing noted.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 was > 1970 mg/kg for male and female rabbits.

Classification as a dermal toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/548/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Executive summary:

The LD50 was > 1970 mg/kg for male and female rabbits.

Classification as a dermal toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/548/EEC for dangerous substances and Directive 1999/45/EC for preparations.