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EC number: 615-086-0 | CAS number: 70225-05-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Conducted according to sound scientific principles. GLP.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 983
- Reference Type:
- publication
- Title:
- Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate
- Author:
- ACC Phthalate Esters Panel HPV Testing Group
- Year:
- 2 006
- Bibliographic source:
- IUCLID 4 Data Set, HPV chemical
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate
- IUPAC Name:
- Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate
- Reference substance name:
- Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
- EC Number:
- 222-020-0
- EC Name:
- Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
- Cas Number:
- 3319-31-1
- Molecular formula:
- C33H54O6
- IUPAC Name:
- tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
- Reference substance name:
- Nuoplaz 6959
- IUPAC Name:
- Nuoplaz 6959
- Details on test material:
- Tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate
Source: Nouplaz 6959, Batch No. 39049, Purity: 98.95%
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Weight at study initiation: 210-275 g for both sexes.
No. of animals per sex per dose: 5 per sex per dose group
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Inhalation Chamber: A 0.5m3 stainless steel inhalation chamber was used. (Youg and Bertke, Cincinnati, Ohio). The test compound atmosphere was generated directly into the chamber by means of Jet Nebulizer Mechanism. Chamber concentrations were monitored by a filter paper/gravimetric technique approximately every 30 min during the exposure period.
The HEPA filtered chamber air-flow was maintained between 10 to 20 air changes per hour during the exposure period with the chamber under slightly negative pressure. The temperature in the chamber was maintained at 69-75 degree F with relative humidity of 30-50% - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 2600 mg/m3
- No. of animals per sex per dose:
- 5 per sex
- Control animals:
- no
- Details on study design:
Clinical observations performed and frequency: After the exposure, all animals were observed daily for 14 days for clinical signs of toxicity. Body weights were recorded prior to exposure and weekly thereafter. All animals were subjected to necropsy at termination of the study.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2 600 mg/m³ air (nominal)
- Based on:
- test mat.
- Remarks on result:
- other: no mortality
- Mortality:
- No deaths were recorded.
- Clinical signs:
- other: All animals (male and female) had matted, drenched coats for the first 2 days, otherwise no visible signs. v
- Body weight:
- The test substance did not cause any changes in body weight.
Mean body weight (g), Mean(S.D.) of rats exposed to this chemical
Males
Initial weight 265.1(8.40)
First week 297.8(14.02)
Second week 329.7(15.27)
Females
Initial weight 213.9(2.66)
First week 223.2(3.96)
Second week 238.1(4.82) - Gross pathology:
- All males and 3/5 females exhibited reddening patches on lungs.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LC50 was determined to be > 2600 mg/m3 in male and female rats.
Classification as an inhalation toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/548/EEC for dangerous substances and Directive 1999/45/EC for preparations. - Executive summary:
The LC50 was determined to be > 2600 mg/m3 in male and female rats.
Classification as an inhalation toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/548/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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