Decanoic acid, mixed diesters with octanoic acid and triethylene glycol

Endpoint summary

Description of key information

With the read across chemical, ethane-1,2-diylbis(oxyethane-2,1-diyl) bis(2-ethylhexanoate) (CAS No. 94 -28 -2), and following a preliminary screening test, three groups, each of five animals, were treated with 50 μl (25 μl per ear) of the undiluted test material or the test material as solution in acetone/olive oil 4:1 at concentrations of 25% or 50% v/v. A further group of 5 animals was treated with acetone/olive oil 4:1 alone. The stimulation index expressed as the mean radioactive incorporation for each treatment group divided by the mean radioactive incorporation of the vehicle control group was 2.33, 1.94 and 2.97 for the 25, 50 and 100% solutions. All test groups were therefore negative for sensitization.

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records

Reference

Endpoint:

skin sensitisation: in vivo (LLNA)

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

The subject material is a member of a US HPV Glycol Esters category.

Reason / purpose for cross-reference:

read-across source

Key result

Parameter:

SI

Value:

2.33

Test group / Remarks:

25% solution

Key result

Parameter:

SI

Value:

1.94

Test group / Remarks:

50% solution

Key result

Parameter:

SI

Value:

2.97

Test group / Remarks:

100% solution

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not sensitising)

Respiratory sensitisation

Endpoint conclusion

Endpoint conclusion:

no study available