Registration Dossier
Registration Dossier
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EC number: 310-288-2 | CAS number: 161907-78-4 A complex mixture of oxygenated hydrocarbons produced by the distillation of residues from the manufacture of ethylene glycol monoethyl ether. It consists predominantly of a mixture of di-, tri-, tetra- and pentaethylene glycol monoethyl ethers having carbon numbers predominantly in the range C6 to C12 and boiling in the range of approximately 200°C to 300°C (392°F to 572°F).
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Measured data: 2-(2-(2-butoxyethoxy)ethoxy)ethanol surrogate: 72hr EC10 (growth rate) = 613mg/l, 2-(2-(2-methoxyethoxy)ethoxy)ethanol, EC10>500mg/l.
QSAR value (EC50) for 2-(2-(2-ethoxyethoxy)ethoxy)ethanol: 3.9g/l.
QSAR value (EC50) for 3,6,9,12-tetraoxatetradecan-1-ol: 7.9g/l.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 3.9 g/L
Additional information
No data is available for the substance the UVCB substance or either of the two main components. There is however measured data for two similar substances either side of it in the homologous series of these triethylene glycol ethers. A full and detailed justification for a category approach for meeting the individual data requirements for glycol ethers to support read across is included as an attachment in chapter 13 to this dossier. For this specific end point, the category document shows a clear trend of decreasing toxicity to aquatic species with reducing length of the alkyl chain length of the alcohol used to produce the glycol ether and increasing number of EO units in the chain. Interpolation from the results of other glycol ethers within the same homologous family of triethylene glycol ethers can be considered a valid approach to meeting the data requirements of this substance.
2-(2-(2 -methoxyyethoxy)ethoxy)ethanol (TEGME) has a measured 72hr EC0 of >500mg/l (maximum tested dose) whereas 2-(2-(2 -butoxyyethoxy)ethoxy)ethanol has a measured 72 hr EC10 of 613mg/l.. Since the logKow is the primary determinant of the likely toxicity, the value for 2-(2-(2 -methoxyyethoxy)ethoxy)ethanol (TEGME) is likely to be closest to actual unknown value for the two main components of this UVCB substance, 2-(2-(2-ethoxyethoxy)ethoxy)ethanol and 3,6,9,12-tetraoxatetradecan-1-ol. The predicted values for the logkow using the ECOSAR QSAR are shown below:
Substance |
Measured values (mg/l) |
QSAR values (mg/l) |
||
NOEC/EC10 |
EC50 |
NOEC/EC10 |
EC50 |
|
TEGME (log Kow = -1.12) |
>500 |
1146 |
8240 |
|
TetraEGEE (logKow = -0.9 |
1133 |
7855 |
||
TEGEE (logKow = -0.6) |
599 |
3904 |
||
TEGBE (logKow = 0.51) |
613 | 148 | 770 | |
2-(2-(2-ethoxyethoxy)ethoxy)ethanol and 3,6,9,12-tetraoxatetradecan-1-ol are the two main components of this UVCB substance. As a conservative approach, the key value for the EC50 (rounded to 2 significant figures) representative of the UVCB substance is taken from the as the lower of the two QSAR predicted EC50 values for these two component substances, i.e. 3.9g/L.
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