Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 310-288-2 | CAS number: 161907-78-4 A complex mixture of oxygenated hydrocarbons produced by the distillation of residues from the manufacture of ethylene glycol monoethyl ether. It consists predominantly of a mixture of di-, tri-, tetra- and pentaethylene glycol monoethyl ethers having carbon numbers predominantly in the range C6 to C12 and boiling in the range of approximately 200°C to 300°C (392°F to 572°F).
Endpoint summary
Administrative data
Description of key information
Additional information
No data is available for the UVCB substance itself so the information required for these end points is obtained by read across and use of data from the main components. A full and detailed justification for a category approach for meeting the individual data requirements for glycol ethers to support read across is included as an attachment in chapter 13 to this dossier. For these specific end points, the category document shows a clear trend of decreasing toxicity to aquatic species with reducing length of the alkyl chain length of the alcohol used to produce the glycol ether and increasing number of EO units in the chain. Interpolation from the results of other similar glycol ethers , particularly those with similar partition coefficients, can be considered a valid approach to meeting the data requirements of this substance.
A number of acute toxicity studies are available in fish, invertebrates and microorganisms for the major component 2-(2-(2-ethoxyyethoxy)ethoxy)ethanol which is practically non-toxic to these organisms. The LD50 was always in excess of the maximum tested dose. A reliable QSAR along with the information from the category document, support the conclusion that that the other major component, 3,6,9,12-tetraoxatetradecan-1-ol, will be less toxic than 2-(2-(2-ethoxyethoxy)ethoxy)ethanol so it seems an acceptable conservative approach to use data from 2-(2-(2-ethoxyethoxy)ethoxy)ethanol in place of absent data for the UVCB substance itself for these three end points.
For algal toxicity, there is no measured data for any components of the UVCB substance. There is however measured data for two substances either side of it in the homologous series of these triethylene glycol ethers. 2-(2-(2 -methoxyyethoxy)ethoxy)ethanol (TEGME) has a measured 72hr EC0 of >500mg/l (maximum tested dose) whereas 2-(2-(2 -butoxyyethoxy)ethoxy)ethanol has a measured 72 hr EC10 of 613mg/l.. Since the logKow is the primary determinant of the likely toxicity, the value for 2-(2-(2 -methoxyyethoxy)ethoxy)ethanol (TEGME) is likely to be closest to actual unknown value for the two main components of this UVCB substance, 2-(2-(2-ethoxyethoxy)ethoxy)ethanol and 3,6,9,12-tetraoxatetradecan-1-ol. As a conservative approach, the key value for the EC50 (rounded to 2 significant figures) representative of the UVCB substance is taken from the as the lower of the two QSAR predicted EC50 values for these two component substances.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
