2-ethylhexyl 4-(dimethylamino)benzoate

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

07 December 2016 to 12 December 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: vapour pressure balance

Key result

Temp.:

25 °C

Vapour pressure:

0.001 Pa

The mean vapour pressure was 5 × 10^-4 Pa at 25 °C.

A visual assessment of the sample following testing confirmed that the test material had not undergone any changes.

Table 1: Summary of Results

	Run 1	Run 2
Correlation	-0.9986	-0.9969
Slope	-4223	-4720
Intercept	10.97	12.45
Log Vp at 25 °C	-3.20	-3.38
Vp (Pa) at 25 °C	6.4 x10^-4	4.1 x10^-4

 

Conclusions:

Under the conditions of this study the vapour pressure of the test material was found to be 5 × 10^-4 Pa at 25 °C.

Executive summary:

The vapour pressure of the test material was determined in accordance with the standardised guidelines OECD 104 and EU Method A.4 under GLP conditions using a vapour pressure balance.

The microbalance was calibrated with a UKAS calibrated 1 mg weight. It was found that 1 µg produced a deflection of 1.02 × 10^-3 V. A quantity of test material (1.0 g) was added to the furnace. The apparatus was then assembled and evacuated to a pressure of less than 1.0 × 10^-5 Torr (1.3 × 10^-3 Pa). After stabilisation at a given temperature, the shutter was opened to allow a stream of vapour to impact upon one balance pan. The temperature and pan deflection were recorded on a chart recorder. The trace obtained enabled the calculation of mass difference. The furnace temperature was then raised in steps of 5 °C and further measurements taken. Two runs were performed between temperatures of 43.5 and 83.5 °C. The same sample was used for each test, with the pressure being kept below 1.0 × 10^-5 Torr throughout the tests.

Under the conditions of the study the vapour pressure of the test material was found to be 5 × 10^-4 Pa at 25 °C.

Description of key information

Under the conditions of the study the vapour pressure of the test material was found to be 5 × 10^-4 Pa at 25 °C.

Key value for chemical safety assessment

Vapour pressure:

0.001 Pa

at the temperature of:

25 °C

Additional information

The vapour pressure of the test material was determined in accordance with the standardised guidelines OECD 104 and EU Method A.4 under GLP conditions using a vapour pressure balance. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

The microbalance was calibrated with a UKAS calibrated 1 mg weight. It was found that 1 µg produced a deflection of 1.02 × 10^-3 V. A quantity of test material (1.0 g) was added to the furnace. The apparatus was then assembled and evacuated to a pressure of less than 1.0 × 10^-5 Torr (1.3 × 10^-3 Pa). After stabilisation at a given temperature, the shutter was opened to allow a stream of vapour to impact upon one balance pan. The temperature and pan deflection were recorded on a chart recorder. The trace obtained enabled the calculation of mass difference. The furnace temperature was then raised in steps of 5 °C and further measurements taken. Two runs were performed between temperatures of 43.5 and 83.5 °C. The same sample was used for each test, with the pressure being kept below 1.0 × 10^-5 Torr throughout the tests.

Under the conditions of the study the vapour pressure of the test material was found to be 5 × 10^-4 Pa at 25 °C.