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Diss Factsheets
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EC number: 227-842-3 | CAS number: 6000-44-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
Groups of 50 male and 50 female F344 DuCrj rats (aged 6 weeks) were given drinking-water containing 0, 2.5 or 5% glycine (equivalent to approximately 0, 2500 or 5000mg/kg bw per day) for 108 weeks. A complete histopathological evaluation performed at necropsy revealed a high incidence of renal calcification in treated and control groups of females (control, 16 out of 41; 2.5%, 15 out of 46; 5%, 13 out of 31). A low incidence of kidney papillomas was reported in females treated with glycine (2.5%, 4 out of 46; 5%, 2 out of 31), but not in males. A renal cell carcinoma was reported in one male (1 out of of 40) treated with 5% glycine. Further detailed histopathology of the urinary system revealed hyperplasia of the transitional epithelium of the renal pelvis in 2 out of 46 of the females at the 2.5% level only. An increased incidence of necrosis of the renal papillae was reported in treated males (2.5%, 2 out of 45; 5%, 3 out of 40) and females (2.5%, 14 out of 46; 5%, 10 out of 31) compared with the controls (0 out of 40 in males; 0 out of 41 in females). A tumour of the transitional epithelium of the renal pelvis was seen in one male control rat (1 out of 40). Owing to the organ distribution and the histological characteristics of the neoplastic lesions observed in the treated animals, with the exception of those in the renal pelvis, the authors concluded that they were spontaneous and not related to administration of glycine. These spontaneous tumours are known to occur in this strain of rats (Kitahori et al., 1994). Lesions of the urinary tract generally occur as a result of the formation of urinary tract calculi induced by exposure at high doses, which causes subsequent chronic irritation and toxicity (Capen et al., 1999; Cohen, 1999).
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- chronic
- Species:
- rat
Justification for classification or non-classification
The available data on carcinogenicity of the read across chemical (glycine) do not meet the criteria for classification.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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