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EC number: 204-145-2 | CAS number: 116-53-0
The substance is corrosive to the skin (Cat. 1B) and causes serious eye damage (Cat. 1).
Skin reactions after 4-hr contact period (means of 6 animals); 0.5 mL dosed
Time postskin contact
Specific effects(selected effects))N=necrosisU = ulceration
N (all animals)
N (all animals)U (1 animal)
N (all animals)U (5 animals)
Skin reactions after a 3-minute contact period (means of 6 animals); 0.5 mL dosed
Specific effects(selected effects)N=necrosisU = ulcerationD = desquamation
N (3 animals)
N (4 animals)
N (5 animals)D (5 animals)
D (5 animals)
Skin irritating/corrosive properties of the test item were investigated in New Zealand rabbits in a study similar to OECD TG 404. Rabbits were exposed for 3 minutes or 4 hours toward 0.5 mL of the undiluted test item and observed for up to 14 days. Full thickness skin corrosion was observed in animal after 3 minutes or 4 hour exposure and was evident already at the first reading at 5 hours after the start of the exposure.
Skin irritating/corrosive properties of the test item were investigated in a valid study similar to OECD TG 404 in New Zealand rabbits. Rabbits were exposed for 3 minutes or 4 hours toward 0.5 mL of the undiluted test item and observed for up to 14 days. Full thickness skin corrosion was observed in animal after 3 minutes or 4 hour exposure and was evident already at the first reading at 5 hours after the start of the exposure, indicating that the substance is corrosive. The results of the key study indicate that the substance should at least be classified as skin corrosive Cat. 1B. Due to the experimental design (first reading after 5 hours but not after 1 hour after the end of the exposure) it remains unclear if the substance falls under Cat. 1A. Corrosive properties were also reported in two other references of insufficient reliability (RL 4) due to insufficient documentation.
There is no reliable study available which investigated effects on the eyes. However, in a study which was not sufficiently documented for assessment (BASF, 1980) irreversible effects on the rabbit eye were described which indicate that the substance causes severe eye damage (e.g. mean cornea score of 3, scar formation). This finding is supported by the results of two other studies of low reliability and is in line with the observation that the substance is skin corrosive.
Based on the available data a classification as skin corrosive Cat. 1B (H314) and causing serious eye damage (Cat. 1; H318) is suggested according to the criteria of Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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