Registration Dossier
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EC number: 204-145-2 | CAS number: 116-53-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
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- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For details on endpoint specific justification please see read-across report in section 13 or find a link in cross-reference “assessment report”.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- assessment report
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 88.1 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 65.2 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Remarks:
- acc. to OECD 202, 2004
- Conclusions:
- Following effect concetrations were derived: 48h-EC50 (Daphnia magna, immobility) = 88.1 mg/L; 48h-NOEC (Daphnia magna, immobility) = 65.2 mg/L.
- Executive summary:
The study used as source investigated acute toxicity to aquatic invertebrates. The study results of the source compound were considered applicable to the target compound. Justification and applicability of the read-across approach (structural analogue) is outlined in the read-across report in section 13 or find a link in cross reference “assessment report”.
Reference
Description of key information
Following effect concentrations were derived: 48h-EC50 (Daphnia magna, immobility) = 88.1 mg/L; 48h-NOEC (Daphnia magna, immobility) = 65.2 mg/L (mean measured, OECD 202, 2003).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 88.1 mg/L
Additional information
A reliable key study is available on acute toxicity to aquatic invertebrates (RL1; read-across from isopentanoic acid). The study was conducted according to OECD 202 (1984) and in compliance with GLP. The study was performed with two replicates (n=2) of ten daphnids. Daphnids were exposed to nominal test concentrations of 0 (water control), 7.78, 13.0, 21.6, 36.0, 60.0 and 100 mg/L test substance over a time period of 48 hours in a static test system. Test concentrations were confirmed on days 0 (from bulk solutions) and 2 (from each test vessel). Deviation from nominal concentrations was <20%. Nonetheless, effect concentrations were based on mean measured values: control < LOD (LOD = 0.8 mg/L), 7.5, 13.0, 23.0, 38.1, 65.2, and 110 mg/L for the treatment groups.
Observations were made at 24 and 48 hours for immobility. Observed adverse effects (immobility) were in part pH-related rather than to inherent toxicity of the test compound: In the preliminary study, pH of the test solutions was not adjusted, and no immobility occurred up to the highest concentration at 100 mg/L. The definitive study was conducted with no pH adjustment, and therefore represents a more conservative estimate of toxicity by including pH-effects. The derived test concentrations were: 48h-EC50 = 88.1 mg/L (mean measured), with a 95% confidence interval of 82.9–93.7 mg/L; 48h-NOEC = 65.2 mg/L (mean measured).
The study fulfilled the validity criteria of the guideline (OECD 202 adopted 1984 and 2004). The study was considered reliable and adequate for the environmental hazard assessment for aquatic organisms.
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