2-methylbutyric acid

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Study initiation date: 2 December 2009 Study completion date: 16 March 2010

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reference:

Composition 0

Qualifier:

equivalent or similar to

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

adopted on 27 July 1995

Deviations:

no

Qualifier:

equivalent or similar to

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

Directive 92/69/EEC, Official Journal L 383 A 1992

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Test material information:

Composition 1

Key result

Water solubility:

45 g/L

Conc. based on:

test mat.

Loading of aqueous phase:

233.3 g/L

Incubation duration:

>= 24 - <= 72 h

Temp.:

20 °C

pH:

2.4

Remarks on result:

other: Incubation at 30°C for the time given; afterwards equilibration at 20°C for 24 hours before determination of solubility

Details on results:

See below!

Details on measurements:

Sample no	Amount of test item [g]	Added volume of water [ml]	Shaking time at 30°C [h]	Analysed carbon concentration [g C/L]	Concentration of the test item [g/L]^1^)	pH value^2)
1	3.505	15	24	27.3	46.5	2.45
2	3.505	15	24	27.2	46.3	2.44
3	3.509	15	48	26.4	44.9	2.44
4	3.504	15	48	26.0	44.3	2.44
5	3.506	15	72	26.3	44.8	2.45
6	3.508	15	72	26.3	44.8	2.44

1) calculated from the carbon concentration of the sample solutions and the carbon content of the pure test item (58.75 %)

2) The purified water used for the tests had a pH value of 8.41.

Summay results for samples 1 to 6:

Arithmetic mean value: 45.3 g/L

SD: 0.90 g/L

Relative SD: 2.0%

Water solubility [g/L] specific to incubation time interval at 30°C:

24 h: 46.4

48 h: 44.6

72 h: 44.8

The relative standard deviation (repeatability) of the concentrations in all six samples was smaller than 15 % and the three duplicate sets of samples showed no tendency of increasing concentration

values. Thus the test was satisfactory.

Conclusions:

Interpretation of results (migrated information): very soluble (> 10000 mg/L)
Water Solubility (at 20°C): 45 g/I

Executive summary:

The water solubility of the test item was determined according to OECD guideline no. 105 [adopted on 27 July 1995] and EU test method A.6 [Directive 92/69/EEC, Official Journal L 383 A 1992] with the flask method. Water solubility (at 20°C): 45 g/l at a pH of 2.45.

The test(s) used to generate this report was (were) carried out in compliance with the principles of Good Laboratory Practice (GLP) in accordance with the currently valid German Chemical Substance Act (Chemikaliengesetz – ChemG), the underlying Commission Directive 2004/10/EC of 11 February 2004 and the relevant OECD decision of the council on 26 November 1997 and that the results fully reflect those found in the study.

Description of key information

Water solublity (OECD 105): 45 g/L at 20°C and a pH of 2.45

Key value for chemical safety assessment

Water solubility:

45 g/L

at the temperature of:

20 °C

Additional information

The water solubility of the test item was determined compliant with GLP according to OECD guideline no. 105 [adopted on 27 July 1995] and EU test method A.6 [Directive 92/69/EEC, Official Journal L 383 A 1992] with the flask method. Water solubility (at 20°C): 45 g/L at a pH of 2.45.