Registration Dossier
Registration Dossier
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EC number: 231-601-8 | CAS number: 7647-18-9
Carcinogenicity
Administrative data
Description of key information
No experimental data on the carcinogenicity of antimony pentachloride were identified. According to Annex 7 and Annex 8 of the REACH Regulation, there are no data requirements for this endpoints for substances with a tonnage of <100 tonnes/year. However, since the assessment of other long-term human health hazards for antimony pentachloride is based on the information available on other antimony substances, including antimony trioxide, it is important to discuss the pertinence of the carcinogenicity evidence available on antimony trioxide, for antimony pentachloride.
Available animal evidence suggests a hypothesis mode of action according to which carcinogenicity and lung toxicity could only be caused by substantial exposure to respirable particles of Sb, which could reach, accumulate/reside long enough and trigger (deep) lung toxicity. On the basis of this hypothesis mode of action, because antimony pentachloride is a corrosive liquid Sb substance, it is unlikely that it can yield particles which could reach and reside in the deep lung. The corrosivity and strong vapours of antimony pentachloride would probably cause local effects in the upper airways, but not the pneumoconiosis and tumor developments which have been observed in humans and animals exposure to antimony, respectively.
On the basis of this hypothesis mode of action and antimony pentachloride’s physico-chemical properties, it can be concluded with certainty that the lung toxicity and carcinogenicity evidence on antimony trioxide is not pertinent or relevant for antimony pentachloride.”
Key value for chemical safety assessment
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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