Registration Dossier
Registration Dossier
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EC number: 200-824-2 | CAS number: 74-95-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Guidance on registration Reference: ECHA-16-G-06-EN Publ.date:November 2016
Practical guide 2: How to report weight of evidence - Reference: ECHA-10-B-05-EN Publ.date: 24/03/2010
"Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals" (ECHA 2008)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxtree - Toxic Hazard Estimation by decision tree approach
- Author:
- Ideaconsult Ltd
- Year:
- 2 016
- Bibliographic source:
- http://toxtree.sourceforge.net/
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs: Chapter R.6. QSARs and grouping of chemicals
Test material
- Reference substance name:
- Dibromomethane
- EC Number:
- 200-824-2
- EC Name:
- Dibromomethane
- Cas Number:
- 74-95-3
- Molecular formula:
- CH2Br2
- IUPAC Name:
- dibromomethane
1
- Specific details on test material used for the study:
- smile: C(Br)Br
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: qualitative estimation
- Remarks on result:
- no indication of irritation
In vivo
Results
- Irritation parameter:
- other: qualitative estimation
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
Q1.Melting
Point[℃]
> 200 No
C(Br)Br
Q2.LogP-3.1 No
C(Br)Br
Q3.Lipid
Solubility[g/kg] 0,01 No
C(Br)Br
Q4.Group
C (C,H,O) No
C(Br)Br
Q9.Group
CN (C,H,O,N) No
C(Br)Br
Q19.Group
CNHal (C,H,O,N,F,Cl,Br or I ) No
C(Br)Br
Q27.Group
CNS (C,H,O,N,S) No
C(Br)Br
Q33.Group
CHal (C,H,O,F,Cl,Br or I ) No
C(Br)Br
Q36.AlphaAlkynes No
C(Br)Br
Q4.Group
C (C,H,O) No
C(Br)Br
Q9.Group
CN (C,H,O,N) No
C(Br)Br
Q19.Group
CNHal (C,H,O,N,F,Cl,Br or I ) No
C(Br)Br
Q27.Group
CNS (C,H,O,N,S) No
C(Br)Br
Q33.Group
CHal (C,H,O,F,Cl,Br or I ) No Class UnknownC(Br)Br
Result: Not irritant
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
