Registration Dossier
Registration Dossier
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EC number: 208-849-0 | CAS number: 543-80-6
Endpoint summary
Administrative data
Description of key information
There are no studies available on skin sensitisation potential of barium di(acetate) available.
However, a GMPT study with barium dichloride was performed in 2010 and based on the results no evidence on skin sensitisation was observed.
Furthermore, a QSAR calculation (Skin Sensitization model (CAESAR) - v. 2.1.6) was performed with acetic acid. Based on the model outcome “acetic acid” may be considered as a non-sensitising substance in the sense of Regulation (EC) No 1907/2006.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Read-across concept:
Barium di(acetate)completely dissolves upon contact with water to Ba2+and 2*CH3COO-. The water solubility (CRC handbook, 2008) of barium di(acetate) indicates a complete dissolution and a rapid formation of Ba2+and 2*CH3COO-(792 mg/L at 25°C). The pH of a saturated aqueous solution of barium di(acetate) is pH 7.9. Considering that systemic human health effects of barium di(acetate) are due the dissolved concentrations of Ba2+and CH3COO-in physiological solutions, read-across to soluble (i.e., > 10 g/L at room temperature) inorganic barium compounds and acetic acid and its salts (i.e., > 10 g/L at room temperature) is performedand considered to be very conservative.
Justification for classification or non-classification
Based on read-across from barium dichloride and acetic acid to barium di(acetate), the substance does not require classification in accordance with regulation (EC) No 1907/2006 (REACH) Annex VII section 8.3.
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