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EC number: 202-719-7 | CAS number: 98-98-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 Apr - 06 May 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- Adopted 24 Apr 2002
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The Department of Health of the Government of the United Kingdom, London, England
Test material
- Reference substance name:
- Pyridine-2-carboxylic acid
- EC Number:
- 202-719-7
- EC Name:
- Pyridine-2-carboxylic acid
- Cas Number:
- 98-98-6
- Molecular formula:
- C6H5NO2
- IUPAC Name:
- pyridine-2-carboxylic acid
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Ltd, Bicester, Oxon, UK
- Age at study initiation: 12-20 weeks
- Weight at study initiation: 2.0-3.5 kg
- Fasting period before study: None
- Housing: individually in suspended cages, and provided environmental enrichment items
- Diet: "Certified Rabbit Diet," not further specified, ad libitum
- Water: mains drinking water, ad libitum
- Acclimation period: at least five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3
- Humidity (%): 30-70
- Air changes (per hr): ≥15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 15 Apr 2008 To: 06 May 2008
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- other: test substance was moistened with distilled water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 g
VEHICLE
- Amount(s) applied: 0.5 mL distilled water was added to moisten the test substance - Duration of treatment / exposure:
- 3 min, 1 and 4 h
- Observation period:
- 7 days
Reading time points: 1, 24, 48 and 72 h, and 7 days after removal of test substance - Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm² on the dorsal area of the trunk of each animal
- % coverage: not specified
- Type of wrap if used: The test substance was introduced under cotton gauze patches on the shorn skin, secured in place with a strip of surgical adhesive tape, and then the trunk of each animal was wrapped in an elasticized corset.
REMOVAL OF TEST SUBSTANCE
- Washing: Residual test substance was removed by gentle swabbing with cotton wool soaked in distilled water.
- Time after start of exposure: preliminary animal: 3 min, 1 and 4 h, additional 2 animals: 4 h
OBSERVATION TIME POINTS
- 1, 24, 48 and 72 h, and 7 days
SCORING SYSTEM:
- Method of calculation: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- In two animals, light brown discolouration of the epidermis was noted as an erythema reading at the 72 h time point. Concurrently, loss of skin elasticity was noted for one of these 2 animals at the same evaluation.
An observation of desquamation was noted at 7 days in one animal, however the skin reaction itself scored a zero, supporting the criteria of full reversibility within 7 days for all animals.
Any other information on results incl. tables
Table 1: Results of Dermal Irritation Evaluation in the Rabbit after Exposure to the Test Substance
Observation time |
1 |
2 |
3 |
|||
|
Erythema |
Edema |
Erythema |
Edema |
Erythema |
Edema |
1 h |
0 |
0 |
1 |
0 |
1 |
0 |
24 h |
2 |
1 |
2 |
2 |
2 |
1 |
48 h |
2 |
1 |
2 |
2 |
2 |
1 |
72 h |
2 |
1 |
2BL |
1 |
1B |
0 |
7 days |
0 |
0 |
0D |
0 |
0 |
0 |
Mean value |
2.00 |
1.00 |
2.00 |
1.67 |
1.67 |
0.67 |
B = Light brown discolouration of the epidermis
L = Loss of skin elasticity
D = Desquamation
Primary Irritation Index (S/6): 17/6 = 2.6
Applicant's summary and conclusion
- Interpretation of results:
- other: no classification required according to Regulation(EC) No. 1272/2008.
- Conclusions:
- The observed Draize scores do not indicate skin irritation potential of picolonic acid. Therefore, no classification is required for picolinic acid according to Regulation(EC) No. 1272/2008.
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