Registration Dossier
Registration Dossier
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EC number: 600-039-9 | CAS number: 10023-48-0
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]-thiazolium
- Type of composition:
- boundary composition of the substance
- State / form:
- solid: particulate/powder
- Reference substance:
- 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]-thiazolium
- Name:
- 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]-thiazolium
- Type of composition:
- legal entity composition of the substance
- State / form:
- solid: particulate/powder
- Reference substance:
- 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]-thiazolium
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The PBT assessment of 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl}ethyl hydrogen phosphate (CAS 10023-48-0) is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2017).
Persistence
Based on experimental findings, the substance is not readily biodegradable (39% ThODNH4/25% ThODNO3 in 28 d, OECD 301F) and has a dissipation half-life of 30 - 40 d at environmentally relevant conditions (25 °C, pH 4.6 – 9.0). Thus, it is concluded that the substance is potentially vP (and P).
Bioaccumulation
The log Kow of the substance is < 0.39 (VEGA 1.2.3, MLogP v.1.0.0). Therefore, the substance does not meet the screening criterion for bioaccumulation (log Kow > 4.5) and is therefore not B or vB.
Toxicity
The available aquatic effect value for the substance is considerably greater than the threshold values of 0.01 mg/L for long-term toxicity (aquatic algae) and 0.01 mg/L for acute toxicity (fish, aquatic invertebrates and algae). Moreover, the substance is not classified according to Regulation EC No 1272/2008. Therefore, the criteria set out in Annex XIII of Regulation (EC) No 1907/2006 are not met and it is concluded that the substance is not T.
In conclusion, the substance is not PBT / vPvB.
Referenceopen allclose all
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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