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EC number: 947-515-5 | CAS number: -
Fish are in general less sensitive to the primary fatty amine ethoxylates compared to algae and daphnia. The available acute fish data for the primary fatty amine ethoxylates category which covers an alkyl chain length range from C16 to C18 reveal a comparable toxicity, independent of this alkyl chain length.
For the calculation of the PNECaquatic bulk it is considered unlikely that fish toxicity will be critical for primary fatty amine ethoxylates . Hence any additional toxicity testing with fish will not add scientific value to the ecotoxicity profile of the primary fatty amine ethoxylates other than for obtaining a lower assessment factor. It is therefore concluded that for scientific reasons and in accordance to REACH legislation further testing on fish has to be avoided for reasons of animal welfare and that based on the weight of evidence available on ecotoxicity data for several cationic surfactants a safety factor of 10 may be applied for the derivation of the PNECaquatic,bulk.
Most of the short-term toxicity fish tests were conducted in a period when no reliable specific method of analyses was available. The concentrations were therefore not analytically verified, the reliability of the results is limited because of the poor solubility of the test substances and partial sorption onto the walls of test vessels or on other surfaces like the surfaces of the test animals. Hence, most of the tests were considered to be valid with restrictions. The available data reveal a comparable toxicity independent of the chain length. A recent GLP study by Gancet (2009) is considered more reliable than the other endpoints, although it was conducted in standard test medium, with LC50 of 0.1 mg/L is used for risk assessment purposes.
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