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EC number: 255-002-6 | CAS number: 40615-36-9
The mutagenic potential of 4,4'-Dimethoxytrityl chloride was investigated in a bacterial reverse gene mutation assay conducted according to OECD 471 with and without metabolic activation. There was no increase of mutant colonies compared to the negative control observed in all strains. Consequently, the target substance is considered to be non-mutagenic.
Results of the pre-experiment:
Table 2: Results of the pre-experiment
Solvent Control (DMSO)
In a reverse gene mutation assay in bacteria conducted according to OECD 471, strains TA98, TA100, TA102, TA1535 and TA1537 of S. typhimurium were exposed to 4,4'-Dimethoxytrityl chloride (99.73% purity) dissolved in DMSO at concentrations of 31.6, 100, 316, 1000, 2500 and 5000 µg/plate in the presence and absence of mammalian metabolic activation. The positive controls induced the appropriate responses in the corresponding strains. There was no evidence of induced mutant colonies over background in all tester strains and both experiments (plate incorporation and pre-incubation). Based on the results, 4,4'-Dimethoxytrityl chloride is considered to be non-mutagenic in the bacterial reverse gene mutation assay.
This study is classified as acceptable. This study satisfies the requirement for Test Guideline OPPTS 870.5100; OECD 471 for in vitro mutagenicity (bacterial reverse gene mutation) data.
Based on the available data, the test item 4,4'-Dimethoxytrityl chloride does not warrant classification for mutagenicity.
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