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EC number: 232-566-1 | CAS number: 9000-91-3
A study was performed to determine the partition coefficient of the test substance, glucoamylase, according to EEC Method A8 and OECD Method 107.
The study was conducted to comply with the requirements of European Council Directive for 91/414/EEC (Annex II) as amended by European Commission Directive 94/37/EC and amended by Commission Regulation (EU) No. 544/2011 Implementing Regulation (EC) Nov 1107/2009 of the European Parliament and of the Council as regards the data requirements for active substances.
The octanol/water partition coefficient of glucoamylase was found to be < 0.05 (log10 Pow = < -1.3).
Because all enzymes are built up of the combination of the same 20 common amino acids, the physical and chemical characteristics are very similar for different enzymes, and hence, read-across from other enzymes should be fully applicable. The logPow value of the present target substance has not been determined but other enzymes have been analysed and the LogPow from literature studies was found to be between -3.1 to -2.95.
In addition, the octanol-water partition coefficient (logPow) for glucoamylase was measured <= -1.3 at 20°C.
Due to the similar nature of enzymes, this value can also be extrapolated to beta amylase.
- Basketter D, Berg N, Broekhuizen C, Fieldsend M, Kirkwood S, Kluin C, Mathieu S, Rodriguez C (2012a). Enzymes in Cleaning Products: An Overview of Toxicological Properties and Risk Assessment/Management. Regul. Toxicol. Pharmacol., 64(1):117-123.
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