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EC number: 600-809-4 | CAS number: 1072-53-3
The test substance, ESA, was administered in single dose to female Sprague-Dawley (SD) to evaluate the lethal dose 50 (LD50) and acute toxicity. A starting dose level was set as 300 ㎎/㎏ because the toxicological information of the test substance was not known. During study period, mortalities, clinical signs and body weight changes and gross findings at necropsy were examined.
In the first and second steps (300 ㎎/㎏), No mortalities and unusual clinical signs were observed during the observation period. In body weights, there were no changes related with the test substance. And abnormal gross findings were not detected in necropsy at the termination of observations.
In the third step (2,000 ㎎/㎏), all animals died on the day of dosing (day 0) and day 1. Crawling position was observed in all animals at 30 minutes after administration.
No. 8 animal died immediately. No. 9 animal showed coma and terminal respiration at 1 hour and died at 2 hours after administration. No. 7 animal had crouching position and piloerection at 1 hour after administration and piloerection persisted on day 0. The animal died on day 1 finally. Necropsy of the decedents revealed the following; In animals died on day 0, glandular stomach was coated with black material and area of liver where is adjacent to stomach was discolored with gray-green. In an animal died on day 1, gastric filling with black substance and black coating in glandular stomach were founded in stomach and area of liver where is adjacent to stomach was discolored with light brown.
Therefore, the test substance ESA is considered to be classified as GHS category 4 (300 < LD50 cut-off ≤ 2,000 ㎎/㎏ b.w.) under present study conditions.
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