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EC number: 233-279-4 | CAS number: 10102-90-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2011-06-28 to 2011-07-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dicopper hydroxide phosphate
- EC Number:
- 235-285-2
- EC Name:
- Dicopper hydroxide phosphate
- Cas Number:
- 12158-74-6
- Molecular formula:
- Cu2HO5P
- IUPAC Name:
- copper(2+) hydroxide phosphate (2:1:1)
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): dicopper hydroxide phosphate
- Batch number: 08004
- CAS number: 12158-74-6
- EC number: 235-285-2
- solid: particulate/powder
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Deutschland
- Age at study initiation: Guinea pigs were young adults at the start of the study.
- Weight at study initiation: 350 - 450 g
- Housing: Guinea-pigs were kept in separate cages.
- Diet (e.g. ad libitum): Commercial feeding mixture was fed ad libitum.
- Water (e.g. ad libitum): Water was supplemented with 1g/l vitamin C. Access was ad libitum.
- Acclimation period: The animals were acclimated and permanently controlled by veterinarians according to DIN ISO 10993-2.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: The fur was removed from the dorsal area of the trunk of the test animals 24 hours before the test.Test material was applied over an area which is approximately 10% of the total body surface.
- % coverage: 10%
- Type of wrap if used: Test substance was held in contact with the skin with gauze dressing and tape throughout a 24 hour exposure period.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not done.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): The animals recieved an effective dose of 2000 mg/kg bodyweight moistened with water to ensure good skin contact. - Duration of exposure:
- 24 hours.
- Doses:
- 2000 mg/kg bodyweight
- No. of animals per sex per dose:
- 5 males and 5 females.
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The test animals were observed frequently during the first day and then at least once each day. The weighing of the test animals was carried out shortly before the test substance was applied and weekly thereafter.
- Necropsy of survivors performed: yes - a necropsy of all animals was carried out after 14 days.
- Other examinations performed:body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed.
- Clinical signs:
- No test animals exhibited adverse physical symptoms or signs of toxicity after the application of the test material over the observation period of 14 days.
- Body weight:
- See tables 1 and 2.
- Gross pathology:
- A through gross pathological examination was performed by a pathologist. No abnormalities were noted in any of the animals.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal LD50 was determined to be > 2000 mg/kg bw.
- Executive summary:
The test material did not induce toxic reactions in any of the test animals after dermal application and within an observation period of 14 days.
This study is considered to be acceptable and to adequately satisfy both the guideline requirement and the regulatory requirement (Regulation (EC) No. 1907/2006; REACH) as a key study for this endpoint. In addition, this study is considered to be acceptable for classification and labelling in accordance with Regulation (EC) No. 1272/2008 (EU CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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