Registration Dossier
Registration Dossier
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EC number: 209-011-7 | CAS number: 552-38-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study Initiation Date: 24 August 2017; Experimental Completion Date: 04 December 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Source: ExxonMobil Research and Engineering (Paulsborro, NJ)
Lot: 17-064163-4
- Expiration date of the lot/batch: 20 March 2019
-Purity test date: 25 September 2017
Appearance: Light grey powder - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 1.45 - < 1.99
- Temp.:
- 25 °C
- Remarks on result:
- not measured/tested
- Remarks:
- the pH value is not specified by the HPLC method
- Details on results:
- Three test substance peaks were detected between approximately 1.5 and 2.8 minutes. The first peak, at approximately 1.5 minutes, eluted before or with the thiourea and was therefore determined to be unretained and was not included in calculations. The next two peaks, at approximately 2.2 and 2.8 minutes, were used to calculate the log Pow of the test substance as 1.45 and 1.99. A weighted average was not reported for the test substance as it is not a group of homologues.
- Executive summary:
The reference substances used in the test had results that were consistent with those listed in OECD TG 117. At 25°C, the average log Powvalues were estimated by the HPLC estimation method to be 1.45 to 1.99 for lithium salicylate.
Reference
Description of key information
At 25°C, the average log Powvalues were estimated by the HPLC estimation method to be 1.45 to 1.99 for lithium salicylate tested in accordance with OECD TG 117.
Key value for chemical safety assessment
Additional information
Since the study was GLP compliant and followed the aforementioned guidelines, the study was given a reliability rating of 1 (reliable without restrictions).
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