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EC number: 247-499-3 | CAS number: 26172-54-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 July 2017 to 11 September 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- Principles of method if other than guideline:
- Isothermogravimetry
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: isothermal thermogravimetry
Test material
- Reference substance name:
- 2-Methyl-4-Isothiazolin-3-One Hydrochloride
- Cas Number:
- 26172-54-3
- Molecular formula:
- C4H5NOS.HCl
- IUPAC Name:
- 2-Methyl-4-Isothiazolin-3-One Hydrochloride
- Test material form:
- solid
- Details on test material:
- MIT.HCl as manufacured has a purity of >99.9% therefore the technical grade and analytical grade are identical
Constituent 1
- Specific details on test material used for the study:
- Batch Number 10013913, Purity >99.9%, Expiry Date 30 November 2018
Analytical grade and technical grade material are identical
Results and discussion
Vapour pressureopen allclose all
- Key result
- Test no.:
- #1
- Temp.:
- ca. 20 °C
- Vapour pressure:
- ca. 0.777 Pa
- Remarks on result:
- other: Calculated
- Key result
- Test no.:
- #2
- Temp.:
- ca. 25 °C
- Vapour pressure:
- ca. 1 Pa
- Remarks on result:
- other: calculated
Any other information on results incl. tables
Temperature [°C] |
1/T [K] | 1000/T [K] | Weight loss [µg/min] | VT[g/cm2h] | log VT |
70 70 70 |
0.00292 | 2.91545 | 36.02 34.55 33.58 |
0.004322 0.004146 0.004030 |
-2.364275 -2.382371 -2.394738 |
80 80 80 |
0.00283 | 2.83286 | 67.64 68.23 66.62 |
0.008117 0.008188 0.007994 |
-2.090615 -2.86843 -2.097214 |
90 90 90 |
0.00275 | 2.75482 | 139.0 140.3 141.7 |
0.016680 0.016836 0.017004 |
-1.777804 -1.773761 -1.769449 |
100 100 100 |
0.00268 | 2.68097 | 266.9 270.0 270.6 |
0.032028 0.032400 0.032472 |
-1.494470 -1.489455 -1.488491 |
Estimation of VT and PT | log VT/at 20°C | -4.2909427 | |||
log PT/at 20°C | -0.1097542 | ||||
PT/at 20°C | 0.7766865 | ||||
PT[Pa]/at 20°C | 7.77E-01 |
||||
Estimation of VTand PT | log VT/at 25°C | -4.0721919 | |||
log PT/at 25°C | 0.0000000 | ||||
PT/at 25°C | 1.0000000 | ||||
PT[Pa]/at 25°C | 1.00E+00 |
Applicant's summary and conclusion
- Conclusions:
- The isothermal thermogravimetric effusion method was applied for the determination of the vapour pressure of 2-Methyl-4-Isothiazolin-3-One Hydrochloride.
A value of the vapour pressure of the test item was determined using the data obtained between 60 °C and 110 °C. The vapour pressure of the test item was calculated (mean of three determinations) to:
7.77 × 10-1 Pa at 20 °C and 1.00 Pa at 25 °C. - Executive summary:
The isothermal thermogravimetric effusion method was applied for the determination of the vapour pressure of 2-Methyl-4-Isothiazolin-3-One Hydrochloride.A value of the vapour pressure of the test item was determined using the data obtained between 60 °C and 110 °C. The vapour pressure of the test item was calculated (mean of three determinations) to:
7.77 × 10-1Pa at 20 °C and 1.00 Pa at 25 °C.
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