Registration Dossier
Registration Dossier
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EC number: 200-607-2 | CAS number: 65-31-6
Endpoint summary
Administrative data
Description of key information
Hydrolysis
HYDROWIN v2.00 program of Estimation Programs Interface (2018) prediction model was used to predict the hydrolysis half-life of test chemical. The estimated half-life of test chemical was evaluated to be 2.718 hrs at pH 7.0 and 16.306 mins at pH 8.0 (at 25ᵒC) respectively. Based on the half-life value (at pH 7.0), it indicates that the test chemical is expected to undergoe moderate hydrolysis in water.
Biodegradation in water
Estimation Programs Interface Suite (2018) was run to predict the biodegradation potential of the test chemical in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that test chemical is expected to be not readily biodegradable.
Bioaccumulation: aquatic / sediment
In accordance with column 2 of Annex IX of the REACH regulation,testing for this endpoint is scientifically not necessary and does not need to be conducted since the test chemicalhas a low potential for bioaccumulation based on logKow ≤ 3.
Adsorption / desorption
In accordance with column 2 of Annex IX of the REACH regulation,testing for this endpoint is scientifically not necessary and does not need to be conducted since the test chemical has a low potential for adsorption based on low octanol water partition coefficient.
Additional information
Hydrolysis
HYDROWIN v2.00 program of Estimation Programs Interface (2018) prediction model was used to predict the hydrolysis half-life of test chemical. The estimated half-life of test chemical was evaluated to be 2.718 hrs at pH 7.0 and 16.306 mins at pH 8.0 (at 25ᵒC) respectively. Based on the half-life value (at pH 7.0), it indicates that the test chemical is expected to undergoe moderate hydrolysis in water.
Biodegradation in water
Predicted data for the test chemical and supporting study for its structurally similar read across substance were reviewed for the biodegradation end point which are summarized as below:
In a prediction using the Estimation Programs Interface Suite (2018), the biodegradation potential of the test chemicalin the presence of mixed populations of environmental microorganisms was estimated. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that test chemical is expected to be not readily biodegradable.
For the test chemical from authoritative database (2017),biodegradation study was conducted for 72 days for evaluating the percentage biodegradability of test chemical by using municipal waste waterplant from outfall on Fourmile Creek near Ankeny, as a test inoculum. The percentage degradation of the test chemical was determined to be 0% degradation by considering test material analysis (14CO2 (N-methyl-labeled) as parameter in 72 days. Thus, based on the percentage degradation, the test chemical was considered to be not readily biodegradable in water.
On the basis of above results for test chemical, it can be concluded that the test chemical can be expected to be not readily biodegradable in nature.
Bioaccumulation: aquatic / sediment
In accordance with column 2 of Annex IX of the REACH regulation,testing for this endpoint is scientifically not necessary and does not need to be conducted since the test chemicalhas a low potential for bioaccumulation based on logKow ≤ 3.
Adsorption / desorption
In accordance with column 2 of Annex IX of the REACH regulation,testing for this endpoint is scientifically not necessary and does not need to be conducted since the test chemical has a low potential for adsorption based on low octanol water partition coefficient.
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