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EC number: 217-940-4 | CAS number: 2014-83-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- OECD 203
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,6-dichlorobenzyl chloride
- EC Number:
- 217-940-4
- EC Name:
- 2,6-dichlorobenzyl chloride
- Cas Number:
- 2014-83-7
- Molecular formula:
- C7H5Cl3
- IUPAC Name:
- 2,6-dichlorobenzyl chloride
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- yes
- Remarks:
- 0.1 ml Aceton
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Hamilton-Buchanan
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Test temperature:
- 21.6 - 23°C
- pH:
- 7.1 - 8.4
- Dissolved oxygen:
- 5.8 - 8.8 mg/L
- Nominal and measured concentrations:
- 0 mg/L
0 mg/L with 0.1 ml Aceton
1 mg/L
1.25 mg/L
1.8 mg/L
2.5 mg/L
3.5 mg/L
10 mg/L
Substance deposit was observed for 1 / 2,5 / 3,5 / 10 mg/L. Concentrations refer to total amount in aquaria not the soluted amount. - Details on test conditions:
- - number of fish/vessel: 10
- test vessel: 10-l aquaria
- static system
- observations: death, behaviour
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- >= 1 - <= 1.25 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 1 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 1.8 mg/L
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- >= 1.25 - <= 1.8 mg/L
- Duration:
- 48 h
- Dose descriptor:
- LC0
- Effect conc.:
- 1 mg/L
- Duration:
- 48 h
- Dose descriptor:
- LC100
- Effect conc.:
- 1.8 mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- LC50 of 2,6-Dichlorobenzyl chloride is between 1 and 1,25 ml/L within 96 h for Danio rerio.
- Executive summary:
The acute toxicity for the test item 2,6-dichlorbenzoyl chloride to zebrafish (Brachydanio rerio) was determined according to OECD-Guideline for Testing of Chemicals No. 203 (1984), EC Commission Directive 84/449/EC Method C.1 (1984) and according to German Chemikaliengesetzt (Texte 16/48 Umweltbundesamt). Testing laboratory was Deptm. Pharma Forschung Toxikologie u. Pathologie at Hoechst AG Frankfurt/Main, Germany. A static test was conducted. Duration of the test was 96 h. 10 test organisms were exposed to 0, 1, 1.25, 2.5, 3.5 and 10 mg/L of 2,6-dichlorbenzoyl chloride, additionally to the solvent control containing 0.1 ml acetone. Water quality parameters (pH, temperature, oxygen content) were determined at time points 0, 3, 24, 72, and 96 hours to be within the acceptable limits. No lethality occurred in the control groups.
At 1 mg/L symptoms were observed but no letality. At 1.25 - 10 mg/L symptoms and lethality were observed.
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