Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 242-358-2 | CAS number: 18479-49-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- non-GLP, lack of test article purity information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted May 12th, 1981
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,7-dimethyloct-1-en-3-ol
- EC Number:
- 242-358-2
- EC Name:
- 3,7-dimethyloct-1-en-3-ol
- Cas Number:
- 18479-49-7
- Molecular formula:
- C10H20O
- IUPAC Name:
- 3,7-dimethyloct-1-en-3-ol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- Animals were housed in fully air-conditioned rooms.
Temperature: RANGE OF 20 - 24 DEGREES CELSIUS
Relative humidity: 30 - 70%
Day/night rhythm: 12h/12h
Diet: 250 ml tap water per animal per day, 130g per animal of Kliba 341 4mm Firma Klingentalmuehle AG CH-4303 Kaiseraugst, Switzerland
Acclimatization period: at least 8 days before the beginning of the study, same housing conditions as during the study.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0,5 ml of undiluted test substance to the test patch (2.5 cm x 2.5 cm)
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3 (1 male, 2 females)
- Details on study design:
- Application site: upper third of the back or flanks
Readings: 30-60 minutes after removal of the test patches and 24h, 48h, 72h after the beginning of application.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
Any other information on results incl. tables
Evalutation of Erythema (R) and Edema (ED):
0 = None
1 = Very slight
2 = Well-defined
3 = Moderate to severe
4 = Severe to very severe
CALCULATION OF THE MEAN ACCORDING TO 83/467/EEC CRITERIA OF JULY 29TH, 1983
(FOR CALCULATION OF THE MEANS OF ERYTHEMA AND EDEMA ONLY READINGS OF 24,48 AND 72 HOURS ARE USED)
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Very slight erythema (the Draize score = 1) and no edema were observed in two rabbits at 4 and 24 hours. For calculation of a mean of erythema and edema score only readings at 24, 48 and 72 hours after patch removal were used. The primary irritation index was calculated to be 0.2, therefore the test article is non-irritant to the rabbit skin. The mean scores per animal were 0.3, 0.0 and 0.3, therefore, the classification according to GHS criteria is also not a skin irritant (no classification).
- Executive summary:
The study performed in compliance with OECD 404 (version adopted in 1981) but not under GLP.
The dose (0.5 mL of the undiluted test article), application of the test substance (semi-occlusive) and the exposure period (4 h) were adequate. 3 rabbits were used (1 male, 2 females); intact skin.
Very slight erythema (the Draize score = 1) and no edema were observed in two rabbits at 4 and 24 hours. For calculation of a mean of erythema and edema score only readings at 24, 48 and 72 hours after patch removal were used. The primary irritation index was calculated to be 0.2, therefore the test article is non-irritant to the rabbit skin. The mean scores per animal were 0.3, 0.0 and 0.3, therefore, the classification according to GHS criteria is also not a skin irritant (no classification).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.