Registration Dossier
Registration Dossier
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EC number: 227-632-1 | CAS number: 5911-08-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (chloromethyl)cyclopropane
- EC Number:
- 227-632-1
- EC Name:
- (chloromethyl)cyclopropane
- Cas Number:
- 5911-08-0
- Molecular formula:
- C4H7Cl
- IUPAC Name:
- (chloromethyl)cyclopropane
- Test material form:
- liquid
- Details on test material:
- Sample # 96-2369
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Age of the rats : about 6 weeks.
Weight : 177 to 210g for males, 164 to 193g for females.
Acclimatisation : minimum 5 days.
5 rats per cage.
Environmental conditions comply with directive 86/609/CEE.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 5mg/kg (constant volume)
- No. of animals per sex per dose:
- 10 males and 10 females.
- Control animals:
- no
- Details on study design:
- Duration of observation after study : 14 days.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality
- Mortality:
- No mortality at 500mg/kg bw.
50% mortality only for females at 2000mg/kg bw.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
