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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1996
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996
Report date:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
(chloromethyl)cyclopropane
EC Number:
227-632-1
EC Name:
(chloromethyl)cyclopropane
Cas Number:
5911-08-0
Molecular formula:
C4H7Cl
IUPAC Name:
(chloromethyl)cyclopropane
Test material form:
liquid
Details on test material:
Sample # 96-2369

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
Age of the rats : about 6 weeks.
Weight : 177 to 210g for males, 164 to 193g for females.
Acclimatisation : minimum 5 days.
5 rats per cage.
Environmental conditions comply with directive 86/609/CEE.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
5mg/kg (constant volume)
No. of animals per sex per dose:
10 males and 10 females.
Control animals:
no
Details on study design:
Duration of observation after study : 14 days.

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
ca. 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
ca. 500 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 500 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality
Mortality:
No mortality at 500mg/kg bw.
50% mortality only for females at 2000mg/kg bw.

Applicant's summary and conclusion