Registration Dossier

Administrative data

Description of key information

There are five study records for acute toxicity, which are reliable with restrictions: one with oral administration and four with subcutaneous

administration. Further one study record with unclear administration of antimontrifluoride has no sufficient reliability and is therefore not used for assessment.

A mouse LD50 oral 804 mg/kg bw was reported. According to this result a classification for acute toxicity oral in Category 4 based on GHS criteria is recommended.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
not specified
Adequacy of study:
other information
Study period:
1959
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
RTECS, ChemIDplus
GLP compliance:
not specified
Test type:
other: not specified
Species:
mouse
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Doses:
not specified
No. of animals per sex per dose:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
804 mg/kg bw
Mortality:
not specified
Interpretation of results:
Category 4 based on GHS criteria
Executive summary:

RTECS and ChemIDplus database entry: mouse LD50 oral 804 mg/kg

Source: Osaka Shiritsu Daigaku Igaku Zasshi.Journal of the Osaka City Medical Center.Vol. 8, Pg. 817, 1959

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
804 mg/kg bw
Quality of whole database:
Dose descriptor from collection of data (RTECS-database). Primary source was not available.

Additional information

According to Regulation (EC) No. 1272/2008 and subsequent regulations, the test item is classified as Acute Tox. 3 H301, H311, H331.

Justification for classification or non-classification