Registration Dossier
Registration Dossier
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EC number: 903-982-7 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1975
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: A scientific review (peer reviewed). No data on GLP. The described method is not equivalent to OECD guideline.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 008
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
- Principles of method if other than guideline:
- -Principle of test: Irritation was evaluated as a part of an acute dermal LD50 study conducted on 10 rabbits. Irritation was assess after a single 24 h occluded dermal application of neat (5000 mg/kg) fenchyl acetate.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,3-dimethyl-8,9-dinorbornan-2-yl acetate
- EC Number:
- 237-588-5
- EC Name:
- 3,3-dimethyl-8,9-dinorbornan-2-yl acetate
- Cas Number:
- 13851-11-1
- Molecular formula:
- C12H20O2
- IUPAC Name:
- 1,3,3-trimethylbicyclo[2.2.1]hept-2-yl acetate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 24 h
- Number of animals:
- 10
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks on result:
- probability of moderate irritation
Any other information on results incl. tables
A single 24 h occluded dermal application of neat (5 g/kg) test material produced moderate erythema (10/10) and slight (1/10) to moderate (7/10) edema, observed after patch removal.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The substance was moderately irritating to the skin of rabbits.
- Executive summary:
Irritation was evaluated as a part of an acute dermal LD50 study conducted on 10 rabbits. A single 24 h occluded dermal application of neat (5 g/kg) test material produced moderate erythema (10/10) and slight (1/10) to moderate (7/10) edema, observed after patch removal. The substance was moderately irritating to the skin.
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