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EC number: 205-748-3 | CAS number: 149-87-1
- Clinical observations: During the study period, there were no abnormalities in clinical signs observed.
- Body weight: A decrease in body weight was observed in 7/10 of the treated animals, 2/5 animals in the control group 24 hours after removal of the challenge exposure application (Day 29). 24 hours after removal of the challenge exposure application (Day 29) of the positive test substance DNCB, a decrease in body weight was observed in 8/10 of the animals in the study group and 5/5 of the animals in the control group. The cause is not clear, but since a similar phenomenon was observed in the control group as well, it was determined that this decrease in body weight did not result from the test material.
- Challenge exposure: Skin reaction was not observed in 10% challenge exposure of the test material solution.
Table 1: Skin Reaction Results
Sensitization Test Material (20% intradermal induction; 20% epidermal induction; 10% challenge exposure)
No. with positive reaction
Positive Reaction Rate
Challenge Control Test Material (10% challenge exposure)
Positive Control (DNCB 0.1% intradermal induction, epidermal induction and challenge exposure)
Challenge Control (DNCB 0.1%, challenge exposure)
The potential for the test material to cause skin sensitization was assessed in a Guinea pig maximisation test, performed according to a methodology similar to that specified in the OCED guideline, 406. Ten Guinea pigs were exposed to the test material. The induction exposure was performed at a concentration of 20 % via intradermal injection followed by epicutaneous application and occluded for 48 hours. The challenge exposure was performed by epicutaneous application at a concentration of 10 % and occluded for 24 hours. Dermal reactions were scored at 24 and 48 hours post challenge. Additional observations were made for clinical signs of toxicity and body weight change. A positive control, 2,4-Dinitrochlorobenzene (DNCB), was run concurrently. Challenge controls were run for both the exposure group and the positive control. Under the conditions of the study no skin reaction was observed in the exposure group, and thus the test material was determined to be non-sensitizing.
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