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EC number: 217-682-2 | CAS number: 1929-82-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.01 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.017 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.001 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 1.127 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.512 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.051 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.178 mg/kg soil dw
- Assessment factor:
- 10
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 3.33 mg/kg food
- Assessment factor:
- 30
Additional information
Conclusion on classification
Aquatic
Short-term L(E)C50 results are available for each of the three trophic levels. In addition long term data is available for all three trophic levels (fish, daphnia and algae).
Fish: Short-term toxicity was investigated in several fish studies (data available from 1978 to 2014). The LC50 (96h) values range from 3.4 mg/L (bluegill sunfish) to 9.1 mg/L (rainbow trout).
One long term toxicity study is available according to OECD 210 giving a NOEC value of 1.38 mg/L for fathead minnow.
Invertebrates: OECD TG 202 acute toxicity tests to Daphnia magna were performed. The EC50 (48h) are between 2.2 mg/L and 5.78 mg/L. One long term daphnia reproduction study (OECD 211) is available with a NOEC (reproduction) of 0.103 mg/L. This endpoint was used to calculate the PNECaquatic. For further details see the PNEC section above.
Algae/Aquatic Plants: Three algal growth inhibition tests and one study with Lemna gibba are available. Exposure of Selenastrum capricornutum gave the lowest ErC50 (72h) value of 1.7 mg/L. The lowest No Observed Effect Concentration was determined for Navicula pellicula of 0.36 mg/L.
Sediment
No experimental data on sediment toxicity are available. Therefore the PNEC sediment was calculated by the equilibrium partitioning method. For further details see the PNEC section above.
Terrestrial
For the terrestrial environment long term toxicity data is available non-target plant and earthworms. A 56-day reproduction study with Eisenia fetida resulted in a NOEC of 3.91 mg/kg dwt (normalised to standard organic matter content of 3.4%) and a NOEC of 1.78 mg/kg (NOEC of 1000 g a.s./ha converted to a NOEC of 1.33 mg/kg dwt at 5 cm soil depth and then converted to standard organic matter content of 3.4%) was the result of a 21-day seedling emergence/growth study.
Due to the fact that nitrapyrin is applied to soil as fertilizer based on its nitrification inhibitor properties several non-GLP/non-standard protocol studies and publications on soil organism (one short-term earthworm and several on plants and soil micro-organism) are available. Soil-micro-organisms can be considered as the most sensitive species based on the nitrification inhibition effect. Roberts et al. (2003 assessed the toxic effects of nitrapyrin according to the OECD TG 216. An EC50 for nitrapyrin was calculated of 3.1 mg/kg dwt soil. Although this represents the most sensitive species and lowest endpoint, it was decided to not use it for the PNEC derivation: The intended use of nitrapyrin is to inhibit nitrification and therefore the PNEC should not be based on effects on soil nitrification as this is the desired effect of the product in the application area. Therefore it is suggested to base the PNEC on nitrapyrin's toxicity against earthworms and non-target plants, where the latter was considered as the most sensitive species and used to calculate the PNECsoil.
STP
An OECD TG 209 respiration inhibition test was performed giving an EC50 value of 112.7 mg/L. This value was used for deriving a PNECstp. For further details see the PNEC section above.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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