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EC number: 232-589-7 | CAS number: 9001-22-3
The objective of this study was to assess the ocular irritation potential of Cellulase when applied as a single dose (0.1 ml) to the eye of New Zealand rabbits. The study was conducted according to OECD Guideline No. 405 and complied with all GLP standards. A sequential approach was used. In the initial test, the test material was applied at 0.1 ml to the left eye and the grade of ocular reaction was recorded at 1, 24, 48 and 72 hours later. The right eye served as control. At the 24-hour reading, fluorescein was instilled and then rinsed with 0.9% NaCl. The eye was then examined with an UV-light to detect corneal damage. A confirmatory test was conducted with 1 rabbit.
No ocular effects were noted during the study. The primary irritation score was 0.0 and Cellulase should be classified as “Non Irritant”.
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