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Diss Factsheets
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EC number: 247-019-2 | CAS number: 25481-21-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Remarks:
- Experimental data of read across substances
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data for the target chemical is summarized based on the read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- WoE report is based on two toxicity to microorganisms studies as-
WoE 2 and WoE 3. - GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- not specified
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- WoE 2: Pseudomonas putida
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 3 h
- Remarks on exposure duration:
- 3 to 16 hr
- Reference substance (positive control):
- not specified
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 105 - < 403 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: EC50 value of test chemical was found to be in range of > 105 to < 403 mg/l.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism. EC50 value of test chemical was found to be in range of > 105 to < 403 mg/l in duration of 3 hr to 16 hr.
- Executive summary:
Data available of the structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on microorganisms. The studies are as mentioned below:
The first study includes toxicity to microorganisms was carried out. Duration of study was 16 hr. Pseudomonas putida was taken as test organisms. As per the toxicity to microorganisms study the 96 hr EC0 and EC50 value was determined to be 105 mg/l and > 105 mg/l respectively.
The second study includes study of toxicity to microorganisms was carried out in accordance with OECD 209. The duration of the study was 3 hr. Source of test chemical was Akzo Nobel Chemicals b.v. Amersfoort. Activated sludge of predominantly domestic sewage was taken as test organism. On the basis of toxicity to microorganisms study the 3 hr EC10, EC20 and EC50 value was determined to be 48 mg/l, 105 mg/l and 403 mg/l (with 95% CI value of 227 to 597 mg/l) respectively.
On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism. EC50 value of test chemical was found to be in range of > 105 to < 403 mg/l in duration of 3 hr to 16 hr.
Reference
Description of key information
On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism. EC50 value of test chemical was found to be in range of > 105 to < 403 mg/l in duration of 3 hr to 16 hr.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 105 mg/L
Additional information
Data available of the structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on microorganisms. The studies are as mentioned below:
The first study includes toxicity to microorganisms was carried out. Duration of study was 16 hr. Pseudomonas putida was taken as test organisms. As per the toxicity to microorganisms study the 96 hr EC0 and EC50 value was determined to be 105 mg/l and > 105 mg/l respectively.
The second study includes study of toxicity to microorganisms was carried out in accordance with OECD 209. The duration of the study was 3 hr. Source of test chemical was Akzo Nobel Chemicals b.v. Amersfoort. Activated sludge of predominantly domestic sewage was taken as test organism. On the basis of toxicity to microorganisms study the 3 hr EC10, EC20 and EC50 value was determined to be 48 mg/l, 105 mg/l and 403 mg/l (with 95% CI value of 227 to 597 mg/l) respectively.
On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism. EC50 value of test chemical was found to be in range of > 105 to < 403 mg/l in duration of 3 hr to 16 hr.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.