Registration Dossier
Registration Dossier
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EC number: 255-527-0 | CAS number: 41741-86-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1978-07-17 to 1978-08-01
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only orientating information about the inhalation hazard but in light of the very low acute toxicity of the substance this stuy is taken into account following a weight of evidence approach.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: H.F. Smyth et al., Am. Ind. Hyg. Ass. J. 23, 95 - 107 (1962)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test
Test material
- Reference substance name:
- Sodium bis[2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)]chromate(1-)
- EC Number:
- 255-527-0
- EC Name:
- Sodium bis[2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)]chromate(1-)
- Cas Number:
- 41741-86-0
- Molecular formula:
- C34 H24 Cr N8 O6 .Na
- IUPAC Name:
- Sodium;chromium(3+);2-[(3-methyl-5-oxido-1-phenylpyrazol-4-yl)diazenyl]benzoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: dust
- Vehicle:
- air
- Details on inhalation exposure:
- Inhalation of atmosphere concentrated with test substance dust at room temperature. For enrichment of air 200 L air/h are led through a 5 cm high layer of test substance.
- Duration of exposure:
- 7 h
- Concentrations:
- Mean concentration: 0.125 mg/L
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 hours
- Frequency of observations and weighing:
* Observation after 3, 10, 30 min and 1, 3 and 7 hours of exposure
* Weight at beginning (1st trial): 558 g (male), 481 g (female)
* Weight at beginning (2nd trial): 633 g (male), 538 g (female)
- Necropsy of survivors performed: yes (14 days after trial start)
Results and discussion
- Preliminary study:
- none
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.125 mg/L air
- Mortality:
- None
- Clinical signs:
- other: None
- Gross pathology:
- No abnormality of organs was detected.
- Other findings:
- After 7 hours of exposure in an atmosphere concentrated with the test substance (at room temperature) no animals died.
Applicant's summary and conclusion
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