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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
chronic toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1995

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
GLP compliance:
not specified

Test material

Test material form:
liquid
Details on test material:
Chemical names: Di(2-ethylhexyl) terephthalate (DEHT); 1,4-Benzenedicarboxylic acid, bis(2-ethylhexyl) ester; Terephthalic acid, bis(2-ethylhexyl) ester; Bis(2-ethylhexyl) terephthalate
Physical form: Liquid (melts at -48 °C)
IUPAC name: Bis(2-ethylhexyl) benzene-1,4-dicarboxylate
EC name: Bis(2-ethylhexyl) terephthalate
EC number: 229-176-9
CAS Registration Number: 6422-86-2
Molecular formula (MF): C24H38O4
Molecular weight (MW): 390.564 g/mol
Stereochemical description: The substance does not contain a stereogenic centre.
URL to ECHA dossier: https://www.echa.europa.eu/web/guest/registration-dossier/-/registered-dossier/15238
URL to PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/22932
URL to ChemIDplus: https://chem.nlm.nih.gov/chemidplus/rn/6422-86-2
URL to HSDB record: http://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@DOCNO+6150
InChI: InChI=1S/C24H38O4/c1-5-9-11-19(7-3)17-27-23(25)21-13-15-22(16-14-21)24(26)28-18-20(8-4)12-10-6-2/h13-16,19-20H,5-12,17-18H2,1-4H3
InChI Key: RWPICVVBGZBXNA-UHFFFAOYSA-N
SMILES code: CCCCC(CC)COC(=O)C1=CC=C(C=C1)C(=O)OCC(CC)CCCC

Test animals

Species:
rat

Results and discussion

Applicant's summary and conclusion