Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

Currently viewing:

Administrative data

Endpoint:
chronic toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1995

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
GLP compliance:
not specified

Test material

Test material form:
liquid
Details on test material:
Chemical names: Di(2-ethylhexyl) terephthalate (DEHT); 1,4-Benzenedicarboxylic acid, bis(2-ethylhexyl) ester; Terephthalic acid, bis(2-ethylhexyl) ester; Bis(2-ethylhexyl) terephthalate
Physical form: Liquid (melts at -48 °C)
IUPAC name: Bis(2-ethylhexyl) benzene-1,4-dicarboxylate
EC name: Bis(2-ethylhexyl) terephthalate
EC number: 229-176-9
CAS Registration Number: 6422-86-2
Molecular formula (MF): C24H38O4
Molecular weight (MW): 390.564 g/mol
Stereochemical description: The substance does not contain a stereogenic centre.
URL to ECHA dossier: https://www.echa.europa.eu/web/guest/registration-dossier/-/registered-dossier/15238
URL to PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/22932
URL to ChemIDplus: https://chem.nlm.nih.gov/chemidplus/rn/6422-86-2
URL to HSDB record: http://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@DOCNO+6150
InChI: InChI=1S/C24H38O4/c1-5-9-11-19(7-3)17-27-23(25)21-13-15-22(16-14-21)24(26)28-18-20(8-4)12-10-6-2/h13-16,19-20H,5-12,17-18H2,1-4H3
InChI Key: RWPICVVBGZBXNA-UHFFFAOYSA-N
SMILES code: CCCCC(CC)COC(=O)C1=CC=C(C=C1)C(=O)OCC(CC)CCCC

Test animals

Species:
rat

Results and discussion

Applicant's summary and conclusion