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EC number: 947-131-8 | CAS number: -
The test was carried out according to the method given in the "Hazardous Substances Regulations" under the U.S. Federal Hazardous
Substances Labelling Act Sect. 191.11 (February 1965).
In to the left eye of six rabbits (3 male, 3 female) 100 g of the test compound was instilled into the conjunctival sac. The eyelids were then held closed for 1 second. After 30 seconds the compound was, as far as possible, flushed out of the eyes of three of the rabbits with warm water for 1 minute.
Observation was done at 24 and 72 hours and 14 days.
A very slight to mild conjunctival reaction was seen in all treated eyes one hour after application of the compound. These reactions subsided slowly over the subsequent days until all had returned to normal by 48 hours (1/3 washed eyes), 6 days (2/3 washed eyes), 10 days (2/3 unwashed eyes) and 14 days (1/3 unwashed eyes). Staining of the conjunctivae by the compound was seen in all three unwashed eyes for up to 72 hours. Transient damage to the surface epithelium of the cornea was seen at one hour only in one rabbit (No.12).
The substance is considere minimal eye irritant in the albino rabbit.
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