Registration Dossier

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

Experimental data on germ cell mutagenicity of TAT-1 are not available.

QSAR Toolbox has identified as structural alert for this property the "H-acceptor-path3-H-acceptor" (mechanistic profile). This alert explores the possibility that a chemical interacts with DNA and/or proteins via non-covalent binding, such as DNA intercalation or groove-binding (Snyder et al. 2006). Among the descriptors potentially accounting for non-covalent interactions, the present molecular framework representing two bonded atoms connecting two H bond acceptors (calculated with software Leadscope Enteprise 2.4.15-6) resulted in an increased sensitivity/specificity for what concerns the Micronucleus training set.

Endpoint conclusion
Endpoint conclusion:
no study available

Genetic toxicity in vivo

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

Experimental data on germ cell mutagenicity of TAT-1 are not available.

QSAR Toolbox has identified as structural alert for this property the "H-acceptor-path3-H-acceptor" (mechanistic profile)

Overall, available information are judged as inconclusive for the classification of the substance.