Dodecanedioic acid, compound with 2,2',2''-nitrilotriethanol (1:2)

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

4 May 2017 to 5 May 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Key result

Water solubility:

> 1 000 g/L

Conc. based on:

test mat.

Temp.:

21.4 °C

pH:

6

Details on results:

PRELIMINARY TEST RESULTS
- An aliquot of 0.5069 g of test material was dispensed and 0.50 mL of water was added. The test was done at room temperature (21.4 °C). The test material dissolved into a slightly cloudy solution. The resulting solution was pH 6.

DEFINITIVE TEST RESULTS
- No definitive test was required since the test material was completely soluble at 1000 g/L.

OBSERVATIONS
- The test material formed a slightly cloudy solution when combined with water at a ratio of 1000 g /L water. The cloudiness could be removed by syringe filtering the sample with a 0.2 μm cellulose acetate filter. A quantitative UV absorbance comparison was made between the filtered and unfiltered solutions by diluting both solutions in methanol (methanol:water 50:50), which fully dissolved the cloudiness of the unfiltered solution. Both were tested using a UV spectrophotometer at 196 nm. The absorbances of the filtered and non-filtered solutions differed by less than 3 %. The solution was still cloudy at the 500 g/L level indicating there is an impurity present in the test material that does not dissolve at greater 500 g/L. This confirmed that the test material was fully soluble at 1000 g/L, with the solids confirmed as an insoluble impurity. No chemical instability was observed during the test.

- The test material had a water solubility of greater than 1000 g/ L at 21.4 °C as determined by OECD Test No. 105.

Conclusions:

Under the conditions of this study, the test material had a water solubility of greater than 1000 g/ L at 21.4 °C.

Executive summary:

The water solubility of the test material was investigated in accordance with the standardised guideline OECD 105, under GLP conditions.

The test material formed a slightly cloudy solution when combined with water at a ratio of 1000 g /L water. The cloudiness could be removed by syringe filtering the sample with a 0.2 μm cellulose acetate filter. A quantitative UV absorbance comparison was made between the filtered and unfiltered solutions by diluting both solutions in methanol (methanol:water 50:50), which fully dissolved the cloudiness of the unfiltered solution. The absorbances of the filtered and non-filtered solutions differed by less than 3 %. The solution was still cloudy at the 500 g/L level indicating there is an impurity present in the test material that does not dissolve at greater 500 g/L.

Under the conditions of this study, the test material had a water solubility of greater than 1000 g/ L at 21.4 °C.

Description of key information

Under the conditions of the study, the test material had a water solubility of greater than 1000 g/ L at 21.4 °C.

Key value for chemical safety assessment

Water solubility:

1 000 g/L

at the temperature of:

21.4 °C

Additional information

The water solubility of the test material was investigated in accordance with the standardised guideline OECD 105, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

The test material formed a slightly cloudy solution when combined with water at a ratio of 1000 g /L water. The cloudiness could be removed by syringe filtering the sample with a 0.2 μm cellulose acetate filter. A quantitative UV absorbance comparison was made between the filtered and unfiltered solutions by diluting both solutions in methanol (methanol:water 50:50), which fully dissolved the cloudiness of the unfiltered solution. The absorbances of the filtered and non-filtered solutions differed by less than 3%. The solution was still cloudy at the 500 g/L level indicating there is an impurity present in the test material that does not dissolve at greater 500 g/L.

Under the conditions of this study, the test material had a water solubility of greater than 1000 g/ L at 21.4°C.