9,10-Anthracenedione, 1,4-diamino-, N,N'-mixed 2-ethylhexyl and hexyl and octyl derivs.

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two hydrolysis studies as-
2. and 3.

GLP compliance:

not specified

Radiolabelling:

not specified

Analytical monitoring:

not specified

Duration:

5 d

Temp.:

25 °C

Remarks:

2. The study was performed at pH 4, 7 and 9, respectively.

pH:

4

Temp.:

50 °C

Remarks:

3. The study was performed at a pH 4, 7 and 9, respectively.

Positive controls:

not specified

Negative controls:

not specified

Transformation products:

not specified

Temp.:

25 °C

DT50:

> 5 d

Remarks on result:

other: 2. Although the exact half-life value of test chemical was not known, but was reported to be stable during a period of 5 days. The study was performed at pH 4, 7 and 9, respectively.

Temp.:

50 °C

DT50:

> 1 yr

Remarks on result:

other: 3. The study was performed at a pH 4, 7 and 9, respectively.

Details on results:

2. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9 & at a temperature of 25⁰C with a corresponding half-life of > 5 days.
3. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9 & at a temperature of 50⁰C with a corresponding half-life of > 1 years.

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis the test chemical can be expected to be > 5 days at 25°C or > 1 yrs at 50°C at pH 4, 7 and 9, respectively.

Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical.The studies are as mentioned below:

The half-life of the test chemicalwas determined at different pH range.The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 25°C and pH 4, 7 and 9, respectively. Although the exact half-life value of test chemical was not known, but was reported to be stable during a period of 5 days.Thus, the half-life value of test chemical can be determined to be > 5 daysat a pH 4, 7 and 9 & at a temperature of 25°C, respectively, indicating that the test chemical is not hydrolysable.

In an another study, the half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9 & at a temperature of 50°C with a corresponding half-life of > 1 years, respectively. Based on this, it is concluded that test chemical is not expected to undergoe hydrolysis under environmental test conditions and thus can be considered to be not hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis the test chemical can be expected to be > 5 days at 25°C or > 1 yrs at 50°C at pH 4, 7 and 9, respectively. Thus, based on this, it can be concluded that the test chemical is not hydrolysable in water.

Description of key information

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis the test chemical can be expected to be > 5 days at 25°C or > 1 yrs at 50°C at pH 4, 7 and 9, respectively.

Key value for chemical safety assessment

Half-life for hydrolysis:

5 d

at the temperature of:

25 °C

Additional information

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical.The studies are as mentioned below:

The half-life of the test chemicalwas determined at different pH range.The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 25°C and pH 4, 7 and 9, respectively. Although the exact half-life value of test chemical was not known, but was reported to be stable during a period of 5 days.Thus, the half-life value of test chemical can be determined to be > 5 daysat a pH 4, 7 and 9 & at a temperature of 25°C, respectively, indicating that the test chemical is not hydrolysable.

In an another study, the half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9 & at a temperature of 50°C with a corresponding half-life of > 1 years, respectively. Based on this, it is concluded that test chemical is not expected to undergoe hydrolysis under environmental test conditions and thus can be considered to be not hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis the test chemical can be expected to be > 5 days at 25°C or > 1 yrs at 50°C at pH 4, 7 and 9, respectively. Thus, based on this, it can be concluded that the test chemical is not hydrolysable in water.