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EC number: 214-154-3 | CAS number: 1100-88-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Sensitization tests on guinea pig (No guideline was followed but a test according to an acceptable standardised method was performed): No evidence of sensitisation was seen in treated animals after the challenge.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: To test for the sensitization potential, a series of exposures was given over a three-week interval.
- Short description of test conditions: Five guinea pigs received nine application of one drop 25 % suspension to clipped abraded back skin, and the other five animals received four sacral intradermal injections of 0.1 ml 1 % solution (w/v). Following a two-week rest period, the animals were challenged for sensitization by applying one drop 25 % concentration of test material. - GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- The LLNA method was not available yet by the time the study was conducted (1970).
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Phosphonium, Benzyltriphenyl-, chloride (active ingredient 100 %) Lot No. 1887-115 K - Species:
- guinea pig
- Strain:
- not specified
- Sex:
- male
- Details on test animals and environmental conditions:
- No data
- Route:
- intradermal and epicutaneous
- Vehicle:
- other: 30 % guinea pig fat in a 1:1 solution of acetone and dioxane
- Concentration / amount:
- Epicutaneous applications: 25 % (5 animals of the test group received nine applications of one drop on clipped abraded back skin)
Intradermal injections: 0.1 ml 1 % solution (w/v) (test material dissolved to 5 % in a 1:1 solution of acetone and dioxane and then diluted to 1 % in dimethyl phthalate. 5 animals of the test group received 4 sacral intradermal injections, one week apart. - Day(s)/duration:
- 3 weeks
- Adequacy of induction:
- not specified
- No.:
- #1
- Route:
- epicutaneous, open
- Vehicle:
- other: thirteen percent guinea pig fat in a 1:1 solution of acetone and dioxane
- Concentration / amount:
- 25 % w/v concentration of test material
- Day(s)/duration:
- not specified/ 1 day
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- 10 animals per dose
- Details on study design:
- RANGE FINDING TESTS:
MAIN STUDY
A. INDUCTION EXPOSURE
- Five guinea pigs received nine applications of one drop 25 % suspension in 30 % guinea pig fat in a 1:1 solution of acetone and dioxane to clipped abraded back skin, and the other five animals received four sacral intradermal injections (one week apart) of 0.1 ml 1 % solution (w/v) (Test material dissolved to 5% in a 1:1 solution of acetone and dioxane and then diluted to 1 % in dimethyl phthalate).
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge: Challenge occurred after two-week rest period
- Exposure period: To test for sensitization potential, a series of exposures was given over a three-week interval.
- Test groups: 10 animals (one drop of solution was applied on intact skin or abraded skin)
- Control group: a set of 10 previously unexposed guinea pigs was similarly treated at this time to serve as controls for the challenge reactions.
- Site: shoulder skin.
- Concentrations: 25 % concentration of test material in 30% guinea pig fat in a 1:1 solution of acetone and dioxane
- Evaluation: 24 hr after challenge
- Challenge controls:
- A set of 10 previously unexposed guinea pigs was similarly treated at this time to serve as controls for the challenge reactions.
- Positive control substance(s):
- no
- Positive control results:
- No positive control was used.
- Key result
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 1 % solution in 4 intradermal injections, then challenge 25% w/v
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Clinical observations:
- No data
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 25% w/v suspension in 9 applications, then challenge with 25% w/v
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Clinical observations:
- no data
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Reading:
- 1st reading
- Group:
- negative control
- Dose level:
- unexposed during 1st phase, then challenge with 25% w/v
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- No data
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- other: not applicable
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Benzyltriphenylphosphonium chloride is not a skin sensitizer when tested on guinea pig.
- Executive summary:
The objective of this study was to determine the potential of Benzyltriphenylphosphonium chloride to induce sensitization effect in guinea pigs. No guideline was followed but a test according to an acceptable standardised method has been performed. In order to test for the sensitization potential a series of standardised exposures was given over a three-week interval. Five guinea pigs received nine applications of one drop 25 % suspension in 30 % guinea pig fat in a 1:1 solution of acetone and dioxane (f.a.d.) to clipped abraded back skin, and the other five animals received four sacral intradermal injections (one week apart) of 0.1 ml 1% solution (w/v). Following a two-week rest period, the animals were challenged for sensitization by applying one drop 25 % concentration of test material in f.a.d. to both shaved intact and clipped abraded skin. A set of ten previously unexposed guinea pigs was similarly treated at this time to serve as controls for the challenge reactions. No evidence of sensitisation was seen in treated animals after the challenge exposure. Benzyltriphenylphosphonium chloride is not a skin sensitizer when tested on guinea pig skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Justification for classification or non-classification
According to GHS criteria, no skin sensitisation is required for the Benzyltriphenylphosphonium Chloride.
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