Registration Dossier
Registration Dossier
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EC number: 204-620-4 | CAS number: 123-34-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 3-18 October 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- Due to technical reasons, relative humidity values (maximum of 80%) outside the expected ranges of 30-70% were recorded occasionally during the study.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mL/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- slightly decreased activity (6 out of 6 animals), hunched back (6 out of 6 animals), sneezing (6 out of 6 animals) and piloerection (4 out of 6 animals), fully reversible 5 days after exposure.
- Body weight:
- No effects
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 is >2000 mg/kg
- Executive summary:
The acute oral toxicity has been assessed by exposure of the substance to 6 female wistar rats at a concentration of 2000 mg/kg according to the OECD 423 test guideline. No toxicity has been observed and the LD50 is determined to be >2000 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
The acute oral toxicity has been assessed by exposure of the substance to 6 female wistar rats at a concentration of 2000 mg/kg according to the OECD 423 test guideline. No toxicity has been observed and the LD50 is determined to be >2000 mg/kg.
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