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EC number: 441-000-4 | CAS number: 121219-07-6 1-ETHOXY-2,3-DIFLUORBENZOL; 1-ETHOXY-2,3-DIFLUOROBENZENE; 2,3-DIFLUOROPHENETOL; DIPHOL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996-08-01 to 1996-08-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- February 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- 29 December 1992
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 1-ethoxy-2,3-difluorobenzene
- EC Number:
- 441-000-4
- EC Name:
- 1-ethoxy-2,3-difluorobenzene
- Cas Number:
- 121219-07-6
- Molecular formula:
- Hill formula: C8H8F2O
- IUPAC Name:
- 1-ethoxy-2,3-difluorobenzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Remarks:
- HsdCpb: WU
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: F. Winkelmann, 33178 Borchen, Germany
- Females nulliparous and non-pregnant: not specified
- Age at study initiation: about 6 to 9 weeks
- Weight at study initiation: 152 - 202 g (mean: 177 g)
- Fasting period before study: ca. 17 h before and 4 h after treatment
- Housing: single, Makrolon cages type III
- Diet: ad libitum, besides fasting period
- Water: ad libitum, besides fasting period, tap water
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 - 25
- Humidity (%): 41 - 77
- Air changes (per hr): not detailed, but room air-conditioned
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To: 08.08.1996 - 29.08.1996
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED:
1.697 mL/kg bw for 2000 mg/kg bw
0.849 mL/kg bw for 2000 mg/kg bw - Doses:
- 1000 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 2000 mg/kg bw: 5 per sex
1000 mg/kg bw: 5 male - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: observation: daily; body weight: on days 2, 4, 6, 8,11, 13, and 15
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- For body weights the group mean value and the difference to the first value, expressed as percentage, were calculated for each measurement.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 3 Deaths occured up to day 3 after treatment.
Male: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: 1000 mg/kg: locomotor disturbance started between 15 to 60 minutes after treatment and lasted on day 1. 2000 mg/kg: Symptoms of intoxication were first seen 1 to 15 minutes after treatment. They lasted up to day 3 and consisted of locomtor disturbance, d
- Gross pathology:
- The rats that died or were sacrificed at the end of the observation period did not show any abnormalities in the macroscopic examination.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- For both sexes the combined LD50 was therefore determined to be >1000 to < 2000 mg/kg bw.
- Executive summary:
An in vivo oral toxicity study according to OECD 401 using the test substance was conducted in rats. Each 5 male and female animals were treated with 2000 mg/kg bw test substance per gavage and observed for 15 days. Furthermore, 5 males were treated with 1000 mg/kg bw test substance. In animals treated with 2000 mg/kg bw symptoms of intoxication were first seen 1 to 15 minutes after treatment. They lasted up to day 3 and consisted of locomotor disturbance, dyspnea, retention of feces, blood crusted snout, salivation, and abdominal position. After treatment with 1000 mg/kg bw locomotor disturbance developed after 15-60 minutes and lasted up to one day. Three male rats from the high dose group died up to day 3 of the study. Body weight development was impaired on day 2 for females and on day 2 and 4 for males treated with 2000 mg/kg bw. Afterwards bodyweight gain was observed. Males treated with 1000 mg/kg bw showed body weight gain on all days.No abnormalities were detected during gross pathological examinations. Based on the observed mortality the LD50 for male rats was determined to be below 2000 mg/kg bw but greater than 1000 mg/kg bw. For females the observed LD 50 was greater than 2000 mg/kg bw. For both sexes the combined LD50 was therefore determined to be >1000 to < 2000 mg/kg bw.
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