Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 273-662-3 | CAS number: 68991-98-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Authoritative database.
Data source
Reference
- Reference Type:
- other: Authoritative database.
- Title:
- Acute oral toxicity study of Belotex PAD (CAS no: 88-38-0) in Rat.
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- The acute oral toxicity test of 4,4'-bis[4,6-bis(anilino)-1,3,5-triazin-2-yl]aminostilbene-2,2'-disulphonic acid (CAS no: 88-38-0) in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 4,4'-bis[4,6-bis(anilino)-1,3,5-triazin-2-yl]aminostilbene-2,2'-disulphonic acid
- EC Number:
- 201-825-0
- EC Name:
- 4,4'-bis[4,6-bis(anilino)-1,3,5-triazin-2-yl]aminostilbene-2,2'-disulphonic acid
- Cas Number:
- 88-38-0
- Molecular formula:
- C44H36N12O6S2
- IUPAC Name:
- 4,4'-bis[4,6-bis(anilino)-1,3,5-triazin-2-yl]aminostilbene-2,2'-disulphonic acid
- Details on test material:
- Name: 4,4'-bis[4,6-bis(anilino)-1,3,5-triazin-2-yl]aminostilbene-2,2'-disulphonic acid
InChI: 1S/C44H36N12O6S2/c57-63(58,59)37-27-35(49-43-53-39(45-31-13-5-1-6-14-31) 51-40(54-43)46-32-15-7-2-8-16-32)25-23-29 (37)21-22-30-24-26-36(28-38(30)64(60,61)62) 50-44-55-41(47-33-17-9-3-10-18-33)52-42(56-44)48-34-19-11-4-12-20-34 /h1-28H, (H,57,58,59)(H,60,61,62)(H3,45,46,49,51,53,54)(H3,47,48,50,52,55,56)/b22-21+
Smiles: S(c1cc(Nc2nc(Nc3ccccc3)nc(n2)Nc2ccccc2) ccc1\C=C\c1c(S(=O)(=O)O)cc(Nc2nc(Nc3ccccc3) nc(n2)Nc2ccccc2)cc1)(=O)(=O)O
- Name of test material: Belotex PAD
- Molecular formula: C44H36N12O6S2
- Molecular weight: 892.978 g/mol
- Substance type:Organic
Constituent 1
- Specific details on test material used for the study:
- Name: 4,4'-bis[4,6-bis(anilino)-1,3,5-triazin-2-yl]aminostilbene-2,2'-disulphonic acid
InChI: 1S/C44H36N12O6S2/c57-63(58,59)37-27-35(49-43-53-39(45-31-13-5-1-6-14-31) 51-40(54-43)46-32-15-7-2-8-16-32)25-23-29 (37)21-22-30-24-26-36(28-38(30)64(60,61)62) 50-44-55-41(47-33-17-9-3-10-18-33)52-42(56-44)48-34-19-11-4-12-20-34 /h1-28H, (H,57,58,59)(H,60,61,62)(H3,45,46,49,51,53,54)(H3,47,48,50,52,55,56)/b22-21+
Smiles: S(c1cc(Nc2nc(Nc3ccccc3)nc(n2)Nc2ccccc2) ccc1\C=C\c1c(S(=O)(=O)O)cc(Nc2nc(Nc3ccccc3) nc(n2)Nc2ccccc2)cc1)(=O)(=O)O
- Name of test material: Belotex PAD
- Molecular formula: C44H36N12O6S2
- Molecular weight: 892.978 g/mol
- Substance type:Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- not specified
- Doses:
- 10000 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed at 10000 mg/kg bw.
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute oral LD50 value was considered to be >10000 mg/kg bw, when rats were treated with 4,4'-bis[4,6-bis(anilino)-1,3,5-triazin-2-yl]aminostilbene-2,2'-disulphonic acid (CAS no: 88-38-0) via oral route.
- Executive summary:
Acute oral toxicity study of 4,4'-bis[4,6-bis(anilino)-1,3,5-triazin-2-yl]aminostilbene-2,2'-disulphonic acid (CAS no: 88-38-0) was conducted in rats at the concentration of 10000 mg/kg bw. No mortality was observed in treated rats at 10000 mg/kg bw. Therefore, LD50 was considered to be >10000 mg/kg bw, when rats were treated with4,4'-bis[4,6-bis(anilino)-1,3,5-triazin-2-yl]aminostilbene-2,2'-disulphonic acid via oral route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
