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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15. 11. 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
other: Guidance Document on the Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances, EUR 20268 EN (2002).
Version / remarks:
2002
Deviations:
no
Qualifier:
according to
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Version / remarks:
First edition 2009-10-01
Deviations:
no
Principles of method if other than guideline:
The laser diffraction based on the Mie-scattering theory was selected for determination. A representative sample, dispersed at an adequate concentration in a suitable liquid, is passed through the beam of a monochromatic light source (laser). A multi-element detector measures the light scattered by the particles at various angles and numerical values relating to the scattering pattern are then recorded for subsequent analysis. These numerical scattering values are then transformed, using an appropriate optical model and mathematical procedure (Mie theory), to yield the proportion of total volume to a discrete number of size classes forming a volumetric particle size distribution
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Mass median aerodynamic diameter:
38 µm
Geometric standard deviation:
1.8
Percentile:
D90
Mean:
64.2 µm
St. dev.:
3.4
Percentile:
D10
Mean:
17.1 µm
St. dev.:
0.8

Table No.1:Results of determination of particle size distribution

Determination

Median

(um)

Diameter on Cumulative 90%

(um)

Diameter on Cumulative 10%

(um)

Span

(-)

1

36.9

62.0

16.9

1.2

2

38.4

64.9

17.6

1.2

3

38.0

64.2

17.1

1.2

4

38.4

65.9

17.1

1.3

5

36.4

62.0

16.4

1.3

Average

37.6

63.8

17.0

1.2

Standard deviation

0.9

1.7

0.4

0.0

Extended uncertainty

1.8

3.4

0.8

-

The value nearest to average was use as the final result of the test. That was the 3rd measurement.

Standard uncertainty is equal to one standard deviation.

Extended uncertainty was calculated by using coefficient 2.

Conclusions:
see Executive summary
Executive summary:

The particle size distribution of the test substance, Reactive Yellow 85 was determined. The laser diffraction method was used.

The procedures used in the study were in accordance with:

Guidance Document on the Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances, EUR 20268 EN (2002).

Standard ISO 13320: 2009 Particle size analysis – Laser diffraction methods, First edition 2009-10-01.

Particle size distribution of test substance, Reactive Yellow 85, is characterized by the following table:

Determination

Median

(mm)

Diameter on Cumulative 90%

(um)

Diameter on Cumulative 10%

(um)

Span

(-)

Final result

38.0

64.2

17.1

1.2

Extended uncertainty

1.8

3.4

0.8

-

Extended uncertainty was calculated by using a coverage factor of 2.

Description of key information

The laser diffraction method was used.The procedures used in the study were in accordance with:

Guidance Document on the Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances, EUR 20268 EN (2002).

Standard ISO 13320: 2009 Particle size analysis – Laser diffraction methods, First edition 2009-10-01.

Additional information

Particle size distribution of test substance, Reactive Yellow 85, is characterized by the following table:

Determination

Median

(um)

Diameter on Cumulative 90%

(um)

Diameter on Cumulative 10%

(um)

Span

(-)

Final result

38.0

64.2

17.1

1.2

Extended uncertainty

1.8

3.4

0.8

-

Extended uncertainty was calculated by using a coverage factor of 2.