4-tert-butylcyclohexanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Principles of method if other than guideline:

Inhalation risk test, where rats were exposed for 8 h to air saturated with vapour of the test substance at 20 °C.

GLP compliance:

no

Remarks:

study performed prior to implementation of GLP

Test type:

other: inhalation risk test (IRT)

Test material

Test material information

Constituent 1

Reference substance name:

4-tert-butylcyclohexanol

EC Number:

202-676-4

EC Name:

4-tert-butylcyclohexanol

Cas Number:

98-52-2

Molecular formula:

C10H20O

IUPAC Name:

4-tert-butylcyclohexan-1-ol

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
A saturated vapour atmosphere was generated by passing air through a 5 cm thick layer of test substance at 20 °C.

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

8 h

Concentrations:

ca. 0.221 mg/L (QSAR; Danish EPA Database, 2004; saturated vapour concentration at 20 °C).

No. of animals per sex per dose:

12

Control animals:

not specified

Details on study design:

- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LC50

Effect level:

> 0.221 mg/L air

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: max. saturated vapour concentration

Mortality:

No mortality occurred.

Clinical signs:

other: No clinical signs were observed.

Gross pathology:

There were no findings at pathology.

Applicant's summary and conclusion

Conclusions:

No mortality and no systemic effects were noted in rats exposed to a saturated vapour atmosphere (at 20 °C) for 8h. Based on these results, the LC50 value was assumed to be greater than 0.221 mg/L (max. saturated vapour concentration). Only limited information on test method (e.g. test animals, inhalation exposure etc.) is provided and thus documentation is insufficient for assessment.