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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
June 26, 2017 - June 28, 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
Deviations:
no
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: CIPAC MT 187
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Specific details on test material used for the study:
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature
- Stability under test conditions: yes
Key result
Percentile:
D10
Mean:
4.5 µm
St. dev.:
0.024
Key result
Percentile:
D50
Mean:
15.85 µm
St. dev.:
0.019
Key result
Percentile:
D90
Mean:
34.93 µm
St. dev.:
0.022
Key result
Percentile:
other: d4,3
Mean:
17.98 µm
St. dev.:
0.012
Remarks on result:
other: Mass moment mean

Table no. 1. Results of particle size distribution

Particles size

1

2

3

4

5

Average

[µm]

d10

4.47

4.48

4.51

4.51

4.53

4.50

d50

15.83

15.84

15.85

15.85

15.88

15.85

d90

34.96

34.95

34.92

34.92

34.91

34.93

* d4,3,[µm]

17.97

17.97

17.98

17.98

18.00

17.98

Average d43, [µm]

17.98

Standard deviation, [µm]

0.012

Relative Standard Deviation, [%]

0.067

* Average d43, [µm] – The mass moment mean (De Brouckere Mean Diameter)

Conclusions:
The average particle size for the test item is 4.50 µm (D10), 15.85 µm (D50), 34.932 µm (D90) and the mass moment mean (D4,3) is 17.98 µm.
Executive summary:

The particle size for the tested substance was determined using a Coulter LS 13 320. The method used was in accordance with OECD guideline 110, CIPAC MT 187 and ISO 13320 -1, following GLP. The volumetric particle size distribution using the laser scattering method was recorded. The average particle size for the test item is 4.50 µm (D10), 15.85 µm (D50), 34.93 µm (D90) and the mass moment mean (D4,3) is 17.98 µm.

Description of key information

Key study: OECD 110, CIPAC MT 187 and ISO 13320 -1. GLP study. The average particle size for the test item is 4.50 µm (D10), 15.85 µm (D50), 34.93 µm (D90) and the mass moment mean (D4,3) is 17.98 µm.

Additional information

Key study: The particle size for the tested substance was determined using a Coulter LS 13 320. The method used was in accordance with OECD guideline 110, CIPAC MT 187 and ISO 13320 -1, following GLP. The volumetric particle size distribution using the laser scattering method was recorded. The average particle size for the test item is 4.50 µm (D10), 15.85 µm (D50), 34.93 µm (D90) and the mass moment mean (D4,3) is 17.98 µm.