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Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Publication

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs of Geranyl propionate
Author:
D. L. J. Opdyke
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology. Vol. 12, Pg. 897, 1974

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as metioned below
Principles of method if other than guideline:
Acute dermal toxicity of 3,7-dimethylocta-2,6-dien-1-yl propanoate (105-90-8) in Rabbit.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Geranyl propionate
EC Number:
203-344-1
EC Name:
Geranyl propionate
Cas Number:
105-90-8
Molecular formula:
C13H22O2
IUPAC Name:
geranyl propionate
Details on test material:
- IUPAC Name: 3,7-dimethylocta-2,6-dien-1-yl propanoate
- Common Name: Geranyl propionate
- Mol. formula: C13H22O2
- Molecular Weight: 210.3148 g/mol
- Smiles: CCC(=O)OC\C=C(/C)\CCC=C(C)C
- InChI: 1S/C13H22O2/c1-5-13(14)15-10-9-12(4)8-6-7-11(2)3/h7,9H,5-6,8,10H2,1-4H3/b12-9+
Specific details on test material used for the study:
- IUPAC Name: 3,7-dimethylocta-2,6-dien-1-yl propanoate
- Common Name: Geranyl propionate
- Mol. formula: C13H22O2
- Molecular Weight: 210.3148 g/mol
- Smiles: CCC(=O)OC\C=C(/C)\CCC=C(C)C
- InChI: 1S/C13H22O2/c1-5-13(14)15-10-9-12(4)8-6-7-11(2)3/h7,9H,5-6,8,10H2,1-4H3/b12-9+

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed in the treated rabbits at 5000 mg/kg bw
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be >5000 mg/kg bw, when rabbits were treated with 3,7-dimethylocta-2,6-dien-1-yl propanoate (105-90-8) by dermal application.
Executive summary:

Acute Dermal toxicity study was conducted by using 3,7-dimethylocta-2,6-dien-1-yl propanoate (105-90-8) in rabbits at the concentration of 5000 mg/kg bw. No Mortality was observed at dose 5000 mg/kg bw. Therefore, LD50 was considered to be >5000 mg/kg bw, when rabbits were treated with 3,7-dimethylocta-2,6-dien-1-yl propanoate (105-90-8) by dermal application.