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EC number: 237-600-9
CAS number: 13863-31-5
The test substance is estimated to be
stable at pH 4, 7 and 9 at 50 °C: its analogue has a half-life period
longer than one year at 25 °C at pH 4, 7 and 9.
Hydrolysis is a common degradation
route in the environment, namely the reaction of a substance with water
with a net exchange of the X group with an OH at the reaction centre
such that RX + H2O → ROH + HX.
Hydrolysis is often dependent upon
pH as the reaction is commonly driven by hydrogen or hydroxide ions.
Hydrolysis kinetics are usually determined experimentally and should be
used to consider the test type and whether parent or degradation product
should be tested.
In the case of CAS 13863-31-5, it
can be estimated that hydrolysis does not occur because there are not
hydrolysable groups in any of the structures; this is also confirmed by
calculation with HYDROWIN 2.0.
Hydrolyzable organic groups are in
fact those groups that can react with water like Esters, Anhydrides,
Amides, Carbammates, Nitriles, Cyanates, Epoxides, Halomethanes,
Alkylhalides, Urea and none of these groups are present within the
substance or their impurities.
A reliable test on the Hydrolysis
was conducted on an analogous substance of the Stilbene Fluorescent
Whitening Agents category, group 3, CAS 16470-24-9, according to
internationally accepted testing guidelines and performed according to
GLP. The two substances (CAS 16470-24-9 and CAS 13863-31-5) are very
similar and are constituted by similar functional groups. The
sulphonation degree is different: CAS 16470-24-9 is tetrasulphonated
instead than CAS 13863-31-5 that is disulphonated, sodium salt. The
difference in sulphonation can have an influence on water solubility,
but not on the hydrolysation potential, since both substances have no
hydrolysable groups in the chemical structure. Quantity and chemical
identity of the impurities have no influence on the possibility of Read
Across for this end point. For further details refer to the Category
Justification Report to section 13 of the dossier.
Hydrolysis was determined at 50 °C
at pH 4, 7 and 9 for the preliminary test in the analogous substance.
The determination of residual test substance was performed by high
performance liquid chromatography (HPLC) using an external standard. The
test substance is stable at pH 4, 7 and 9 at 50 °C: it has a half-life
period longer than one year at 25 °C at pH 4, 7 and 9.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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