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EC number: 204-465-2 | CAS number: 121-33-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No details on study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- No information
- Author:
- OPDYKE DLJ
- Year:
- 1 977
- Bibliographic source:
- Food Cosmet Toxicol, 15(6), 633-638
- Reference Type:
- publication
- Title:
- No information
- Author:
- STRAND LP, SCHELINE RR
- Year:
- 1 975
- Bibliographic source:
- Xenobiotica, 5(1), 49-63
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Vanillin
- EC Number:
- 204-465-2
- EC Name:
- Vanillin
- Cas Number:
- 121-33-5
- Molecular formula:
- C8H8O3
- IUPAC Name:
- 1-butoxypropan-2-ol
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on exposure:
- A single oral administration to rats of 100 mg/kg bw resulted in the urinary excretion of most of its metabolites within 24 hours, mainly as
glucuronide and/or sulphate conjugates, although the acids formed were also excreted free and as their glycine conjugates. - Duration and frequency of treatment / exposure:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg/kg bw
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
Results and discussion
Metabolite characterisation studies
- Details on metabolites:
- In 48 hours, 94% of the dose had been excreted, in the following proportions:
7% vanillin, 47% vanillic acid, 19% vanillyl alcohol, 10% vanilloylglycine, 8% catechol, 2% 4-methylcatechol, 0.6% 4-methylguaiacol, and 0.5% guaiacol.
No metabolites were found in the urine collected 48-96 hours after dosing.
Any other information on results incl. tables
The conversion of vanillin to vanillic acid was demonstrated in human and rat liver cells in culture (Discher & Brisse, 1966).
An early study found only traces amounts of vanillin in the urine of rabbits given 2g/day orally (about 1g/kg bw/day), the vanillin being conjugated with sulfuric acid. Most of the dose was oxidized to vanillic acid, and this too was excreted as ethereal sulfate conjugate (Preusse, 1880).
Applicant's summary and conclusion
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